Plasma metabolomics are associated with metabolic syndrome: A targeted approach.

Autor: Carioca AAF; Department of Nutrition, School of Public Health, University of Sao Paulo, SP, Brazil; University of Fortaleza (UNIFOR), Nutrition Course, Fortaleza, Brazil. Electronic address: carioca@unifor.br., Steluti J; Department of Nutrition, School of Public Health, University of Sao Paulo, SP, Brazil., Carvalho AM; Department of Nutrition, School of Public Health, University of Sao Paulo, SP, Brazil., Silva AM; Department of Nutrition, School of Public Health, University of Sao Paulo, SP, Brazil., Silva IDCGD; Department of Gynecology, Paulista School of Medicine, Federal University of Sao Paulo, SP, Brazil., Fisberg RM; Department of Nutrition, School of Public Health, University of Sao Paulo, SP, Brazil., Marchioni DM; Department of Nutrition, School of Public Health, University of Sao Paulo, SP, Brazil.
Jazyk: angličtina
Zdroj: Nutrition (Burbank, Los Angeles County, Calif.) [Nutrition] 2021 Mar; Vol. 83, pp. 111082. Date of Electronic Publication: 2020 Nov 20.
DOI: 10.1016/j.nut.2020.111082
Abstrakt: Objectives: Advances in metabolomic tools have allowed us to gain a more comprehensive understanding of metabolic syndrome (MetS). The aim of this study was to evaluate the association between plasma metabolomic profiles and MetS.
Methods: For this study, adults without diabetes, chronic kidney disease, stroke, heart disease, or cancer and with full metabolomics, biochemical, and dietetic data available, representing a subsample of the Health Survey of Sao Paulo study (ISA-Capital; N = 130), were included. The joint interim statement consensus criteria were used for diagnosing MetS. Absolute quantification (µmol/L) of blood metabolites was achieved by targeted quantitative profiling of annotated metabolites by electrospray ionization tandem mass spectrometry in plasma samples. Mean differences in the compounds for MetS were evaluated by linear regression adjusted for confounding factors.
Results: Serine was inversely associated with MetS (β = -15.04; P = 0.014). In glycerophospholipids with acyl-alkyl bonds, there was an inverse association with MetS, including phosphatidylcholine (PC) ae C42:5 (β = -0.15; P = 0.040), PC ae C44:5 (β = -0.15; P = 0.046), PC ae C40:4 (β = -0.21; P = 0.014) and PC ae C44:4 (β = -0.04; P = 0.032).
Conclusion: Plasma metabolomic profiles were associated with MetS, especially the amino acid serine and some acyl-alkyl PCs.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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