| Autor: |
Vidrascu EM; Department of Psychology, Howell Hall, University of North Carolina, Chapel Hill, North Carolina.; Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina., Robertson MM; Department of Psychology, Howell Hall, University of North Carolina, Chapel Hill, North Carolina.; Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of neurophysiology [J Neurophysiol] 2021 Feb 01; Vol. 125 (2), pp. 533-536. Date of Electronic Publication: 2020 Dec 23. |
| DOI: |
10.1152/jn.00439.2020 |
| Abstrakt: |
Adaptive behavior in response to adverse experiences facilitates faster recovery and less time spent engaging in maladaptive behaviors that contribute to psychopathology, including anxiety, depression, and posttraumatic stress disorder. Dysregulation of activity in the prefrontal cortex (PFC) has been implicated in these disorders, with stress further exacerbating these negative effects. Corticotropin-releasing factor is an important regulator of the stress-response system and may have a differential involvement in individuals who are especially susceptible to negative stress-related outcomes. A recent study by Chen et al. (Chen P, Lou S, Huang ZH, Wang Z, Shan QH, Wang Y, Yang Y, Li X, Gong H, Jin Y, Zhang Z, Zhou Z. Neuron 106: 301-315, 2020) has identified a novel subtype of GABAergic CRF interneurons in the dorsomedial PFC that, upon activation, can promote active responses and resilient behavior in response to stress. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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