Association of gestational diabetes mellitus and thyroid status during pregnancy: a cross-sectional study in a tertiary health care center of Bangladesh.

Autor: Shahid MM; Department of Endocrinology, Ad-Din Women's Medical College, Dhaka, Bangladesh., Rahman KMT; Department of Public Health and Informatics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh., Gomes RR; Department of Internal Medicine, Ad-Din Women's Medical College, Dhaka, Bangladesh., Ferdous M; Department of Gynecology and Obstetrics, Shaheed Suhrawardy Medical College, Dhaka, Bangladesh., Ferdousi S; Department of Pathology, Dr. Sirajul Islam Medical College, Dhaka, Bangladesh., Zahan T; Farida Clinic and Infertility Management Center, Dhaka, Bangladesh.
Jazyk: angličtina
Zdroj: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2021 Apr; Vol. 37 (4), pp. 312-314. Date of Electronic Publication: 2020 Dec 28.
DOI: 10.1080/09513590.2020.1866531
Abstrakt: Objective: To find out any association between gestational diabetes mellitus (GDM) and thyroid status (TS) throughout pregnancy in Bangladesh.
Methodology: This study, designed as a cross-sectional study, was performed on randomly chosen 628 patients attending the Ad-Din Women's Medical College antenatal service from January 1 2019 to December 31 2019. After taking a detailed history, oral glucose tolerance test was done for all the participants. If eligible, then thyroid-stimulating hormone (TSH) and free thyroxine (F.T4) tests were done. t -test and Chi-square test were used to compare variables between various classes as necessary.
Results: The mean gestational age in GDM and non-GDM groups was 20.5 ± 9.1 years and 17.5 ± 9.2 years, which were significantly different ( p <.001). There was a substantial ( p <.001) high incidence of thyroid disorder (TD) in the non-GDM community. Mean F.T4 of the GDM group was lower in all three trimesters. The mean TSH of the GDM group was more deficient in the early stage of pregnancy but higher in the later stage (3rd trimester). Euthyroid cases were significantly higher (83.8%; p <.001) while subclinical hypothyroidism (9.5%; p <.001) and transient hyperthyroidism (2.4%; p <.001) cases were significantly lower in GDM group.
Conclusions: Even though GDM and TD are the most prevalent endocrine disorders during pregnancy, neither TS during pregnancy nor any risk factors for TD have been associated with the development of GDM.
Databáze: MEDLINE
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