Idiopathic Terminal Ileal Ulceration Mimicking Crohn's in the Setting of Antiretroviral Therapy Initiation.

Autor: Nasir UM; Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ., Paer J; Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ., Jiang Y; Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ., Mirani NM; Department of Pathology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ., Ahlawat S; Division of Gastroenterology, Rutgers New Jersey Medical School, Newark, NJ., Pergament KM; Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ.
Jazyk: angličtina
Zdroj: ACG case reports journal [ACG Case Rep J] 2020 Dec 16; Vol. 7 (12), pp. e00489. Date of Electronic Publication: 2020 Dec 16 (Print Publication: 2020).
DOI: 10.14309/crj.0000000000000489
Abstrakt: Antiretroviral therapy (ART) has precipitously decreased the morbidity associated with human immunodeficiency virus but can unmask and exacerbate opportunistic infections and autoimmune diseases. Various diseases have been reported in association with ART initiation, but there is scant literature describing inflammatory colitis in the setting of ART initiation. We present a 39-year-old man with chronic untreated human immunodeficiency virus and central nervous system toxoplasmosis who developed persistent diarrhea after initiation of ART. A comprehensive infectious workup was negative. Computed tomography demonstrated terminal ileum enteritis, which was confirmed by colonoscopy. Biopsy of the terminal ileum revealed fibrinous exudate and granulation tissue.
(© 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.)
Databáze: MEDLINE