Inflammation and Oxidative Stress in Deficit Schizophrenia.
| Autor: | KÖŞger F; Department of Psychiatry, Eskişehir Osmangazi University School of Medicine, Eskişehir, Turkey., YİĞİtaslan S; Department of Medical Pharmacology, Eskişehir Osmangazi University School of Medicine, Eskişehir, Turkey., EŞsİzoĞlu A; Freelance Psychiatrist, Eskişehir, Turkey., GÜleÇ G; Department of Psychiatry, Eskişehir Osmangazi University School of Medicine, Eskişehir, Turkey., KarataŞ RD; Department of Psychiatry, Eskişehir City Hospital, Eskişehir, Turkey., DeĞİrmencİ SS; Freelance Psychiatrist, Mainz, Deutschland. |
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| Jazyk: | angličtina |
| Zdroj: | Noro psikiyatri arsivi [Noro Psikiyatr Ars] 2020 Sep 21; Vol. 57 (4), pp. 303-307. Date of Electronic Publication: 2020 Sep 21 (Print Publication: 2020). |
| DOI: | 10.29399/npa.24966 |
| Abstrakt: | Introduction: Differences in parameters related to inflammatory and oxidative stress in deficit (DS) and nondeficit schizophrenia (non-DS) may support the DS/non-DS categorization of schizophrenia. For DS patients, non-DS patients, and for healthy controls, this study aims to evaluate the serum levels of: proinflammatory cytokines of interleukin (IL) 1β, tumor necrosis factor (TNF) α, Interferon (IFN) γ, IL-12, and IL-17; anti-inflammatory cytokines of IL-10, IFN-α, and transforming growth factor (TGF) β; and antioxidant biomarkers of paraoxonase1 (PON1) and Total Antioxidant Capacity (TAOC). Method: Serum IL-1β, TNF-α, IFN-γ, IL-12, IL-17, IL-10, IFN-α, TGF-β, PON1 and TAOC levels were measured and performed in DS (n=26), non-DS (n=28), and healthy control (n=28) groups. Results: Patients in the DS group had higher IL-17 levels than the non-DS group did. TGF-β values for both patient groups were significantly higher than those of the controls. PON1 and TAOC values for both patient groups were significantly lower than those of the controls. Conclusion: Our findings may be evidence for the consideration that DS reflects a coherent entity within schizophrenia. Increased levels of IL-17 from pro-inflammatory cytokines may be related with DS. Competing Interests: Conflict of Interest: The authors have no competing interests to report. (Copyright: © 2020 Turkish Neuropsychiatric Society.) |
| Databáze: | MEDLINE |
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