Brief Report: HIV-1 Seroconversion Is Not Associated With Prolonged Rectal Mucosal Inflammation.

Autor:	Blair CS; Department of Medicine, Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA., Lake JE; Department of Medicine, Division of Infectious Diseases, McGovern Medical School at University of Texas at Houston, Houston, TX., Passaro RC; Department of Emergency Medicine, Keck School of Medicine at the University of Southern California, Los Angeles, CA., Chavez-Gomez S; Asociación Civil Via Libre, Lima, Peru., Segura ER; Department of Medicine, Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA.; Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas, Lima, Peru ; and., Elliott J; Department of Medicine, Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA., Fulcher JA; Department of Medicine, Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA., Shoptaw S; Department of Family Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA., Cabello R; Asociación Civil Via Libre, Lima, Peru., Clark JL; Department of Medicine, Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Jazyk:	angličtina
Zdroj:	Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2021 Apr 15; Vol. 86 (5), pp. e134-e138.
DOI:	10.1097/QAI.0000000000002601
Abstrakt:	Objective: Determine the impact of HIV-1 seroconversion on inflammatory cytokines in the rectal mucosa. Setting: Secondary analysis of data from men who have sex with men and transgender women who participated in a HIV prevention trial Lima, Peru. Methods: From July to December 2017, 605 men who have sex with men and transgender women were screened for rectal gonorrhea/chlamydia (GC/CT). Fifty GC/CT-positive cases were randomly selected and matched with 52 GC/CT-negative controls by age and number of receptive anal intercourse partners in the last month. All participants were HIV-negative at baseline and those with GC/CT at baseline and/or follow-up received appropriate antibiotic therapy. Participants underwent sponge collection of rectal secretions for the measurement of inflammatory cytokines (IL-1β, IL-6, IL-8, and TNF-α) and were screened for rectal GC/CT and HIV at baseline, 3 months, and 6 months. Wilcoxon rank-sum tests compared inflammatory cytokine levels between participants diagnosed with HIV during follow-up and persons who remained HIV-negative. Results: Eight participants were diagnosed with HIV at the 3-month (n = 6) or 6-month (n = 2) visit. The median number of receptive anal intercourse partners in the month before HIV diagnosis was the same for those who acquired HIV and those who did not. There were no significant differences in inflammatory cytokine levels in rectal mucosa between participants who did and did not experience HIV seroconversion at any time point. Conclusions: Despite a surge in viral replication during acute infection, findings from this study suggest that there is no prolonged effect of HIV-1 seroconversion on inflammatory cytokine levels in the rectal mucosa. (Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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