[The efficacy of outpatient monitoring of children and adolescents with type 1 diabetes with regular use of professional continuous glucose monitoring].

Autor:	Peterkova VA; Endocrinology Research centre., Emelyanov AO; Endocrinology Research Centre., Laptev DN; Endocrinology Research Centre., Samoylova YG; Siberian State Medical University., Khramova EB; Tyumen State Medical University., Petriaikina EE; Morozov Children's Municipal Clinical Hospital of the Moscow City Health Department., Rybkina IG; Morozov Children's Municipal Clinical Hospital of the Moscow City Health Department., Filimonova AY; Regional Children Clinical Hospital named after N.V. Dmitrieva.
Jazyk:	ruština
Zdroj:	Problemy endokrinologii [Probl Endokrinol (Mosk)] 2020 Aug 04; Vol. 66 (1), pp. 14-22. Date of Electronic Publication: 2020 Aug 04.
DOI:	10.14341/probl12200
Abstrakt:	Background: According to research, only 38% of patients reach glycated hemoglobin targets. It is possible to improve the effectiveness of medical care for children with T1D using modern technologies, including continuous glucose monitoring (CGM). Aims: To evaluate the effectiveness of outpatient monitoring of children and adolescents with T1D with regular use of professional continuous glucose monitoring. Methods: The inclusion criteria: age 8−12 years; T1D at least 1 year; insulin therapy by multiple injections of insulin; inadequate glycemic control of T1D: НbА1с level of 7.5% and higher and / or children and adolescents with frequent episodes of hypoglycemia (usually 4 times a week) or with a history of severe hypoglycemia; signed informed consent. All patients initially and 12 weeks after inclusion in the study conducted a study of the level of НbА1с, and also performed CGM for 6 days. Based on the results of CGM, glycemia indicators and daily doses of insulin were recorded, treatment was evaluated and corrected, and recommendations for self-monitoring were made. Glucose monitoring was carried 120−144 hours using the blind method iPro2 (Medtronic, USA). Results: In all, 99 children aged 8−18 years were included in the study in all centers. The decrease in the level of НbА1с by the end of the study was 0.72%, while the proportion of patients who reached the target level of НbА1с (defined as <7.5%) was statistically significantly higher at the end of the study (15.5% and 2%, respectively; p<0.05). During the study, patients showed a trend towards a decrease in the average level and variability of glycemia by the end of the study, however, statistical significance was achieved only in relation to the average level of glycemia (p=0.04). Conducted insulin therapy, determined by the average daily doses of long-acting and short-acting insulin, did not statistically significantly change at the end of the study. The frequency of DKA episodes and severe hypoglycemia did not statistically significantly differ from the initial level. Conclusions: For children with poor glycemic control of T1D, the use of professional CGM is effective in terms of glycemic control and a safe method.
Databáze:	MEDLINE
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