Usual opioid dosing does not adversely affect the course of healthcare-associated Clostridioides difficile infection.

Autor: Chowdhry M; West Virginia University Health Sciences Center, Charleston Division/Charleston Area Medical Center, Charleston, WV 25304, USA., Haden D; Department of Critical Care/Pulmonary Disease, Atrium Health's Carolinas Medical Center, 1000 Blythe Blvd, Charlotte, NC 28203, USA., Kemper S; West Virginia University Health Sciences Center, Charleston Division/Charleston Area Medical Center, Charleston, WV 25304, USA., Helmick K; West Virginia University Health Sciences Center, Charleston Division/Charleston Area Medical Center, Charleston, WV 25304, USA., Kawsara M; Department of Internal Medicine, West Virginia University Health Sciences Center, Morgantown, 1 Medical Center Drive, Morgantown, WV 26505, USA., Huggett A; Department of Internal Medicine, Prisma Health/University of South Carolina School of Medicine, 2 Medical Park, Columbia, SC 29203, USA., Stark A; West Virginia University Health Sciences Center, Charleston Division/Charleston Area Medical Center, Charleston, WV 25304, USA., Khan A; West Virginia University Health Sciences Center, Charleston Division/Charleston Area Medical Center, Charleston, WV 25304, USA., Shah M; Addiction Science Center, University of Cincinnati Medical Center, 3132 Harvey Ave., Cincinnati, OH 45239, USA., Bhaty M; Department of Internal Medicine, Southside Regional Medical Center, 200 Medical Park Blvd. Petersburg, VA 23805, USA., Farooq J; West Virginia University Health Sciences Center, Charleston Division/Charleston Area Medical Center, Charleston, WV 25304, USA., Singh S; West Virginia University Health Sciences Center, Charleston Division/Charleston Area Medical Center, Charleston, WV 25304, USA., McJunkin B; West Virginia University Health Sciences Center, Charleston Division/Charleston Area Medical Center, Charleston, WV 25304, USA.
Jazyk: angličtina
Zdroj: Pain management [Pain Manag] 2021 Mar; Vol. 11 (2), pp. 151-157. Date of Electronic Publication: 2020 Dec 22.
DOI: 10.2217/pmt-2020-0066
Abstrakt: Aim: We sought to determine if opioid exposure may have a detrimental effect on the course of Clostridioides difficile infection (CDI). Materials & methods: We compared opioid exposure in patients with well-defined severe CDI and non-severe CDI. Results: Following exclusions, 403 records were reviewed. Of this group, 128/403 (31.7%) were determined to have severe CDI by strict criteria, and 275/403 (68.3%) were found to have non-severe CDI. Full multivariate regression and reduced model of potential predictors for severe CDI showed no association with opioids prescribed. Conclusion: Opioid exposure (predominantly in modest range) does not appear to be a risk factor for severe healthcare-associated CDI.
Databáze: MEDLINE
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