Plasma and Peritoneal Ceftriaxone Concentrations After Intraperitoneal Administration in Horses With Septic Peritonitis.

Autor: Alonso JM; Department of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, Univ. Estadual Paulista (Unesp), Botucatu, Brazil., Martins ES; Department of Natural Active Principles and Toxicology, School of Pharmaceutical Sciences, Univ. Estadual Paulista (Unesp), Araraquara, Brazil., Peccinini RG; Department of Natural Active Principles and Toxicology, School of Pharmaceutical Sciences, Univ. Estadual Paulista (Unesp), Araraquara, Brazil., Rosa GS; Department of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, Univ. Estadual Paulista (Unesp), Botucatu, Brazil., Guerra ST; Department of Animal Production and Preventive Veterinary Medicine, School of Veterinary Medicine and Animal Science, Univ. Estadual Paulista (Unesp), Botucatu, Brazil., Ribeiro MG; Department of Animal Production and Preventive Veterinary Medicine, School of Veterinary Medicine and Animal Science, Univ. Estadual Paulista (Unesp), Botucatu, Brazil., Santos B; Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, Univ. Estadual Paulista (Unesp), Botucatu, Brazil., García HDM; Department of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, Univ. Estadual Paulista (Unesp), Botucatu, Brazil., Watanabe MJ; Department of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, Univ. Estadual Paulista (Unesp), Botucatu, Brazil., Takahira RK; Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, Univ. Estadual Paulista (Unesp), Botucatu, Brazil., Rodrigues CA; Department of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, Univ. Estadual Paulista (Unesp), Botucatu, Brazil., Alves ALG; Department of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, Univ. Estadual Paulista (Unesp), Botucatu, Brazil., Hussni CA; Department of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, Univ. Estadual Paulista (Unesp), Botucatu, Brazil. Electronic address: carlos.hussni@unesp.br.
Jazyk: angličtina
Zdroj: Journal of equine veterinary science [J Equine Vet Sci] 2021 Jan; Vol. 96, pp. 103310. Date of Electronic Publication: 2020 Oct 24.
DOI: 10.1016/j.jevs.2020.103310
Abstrakt: Intraperitoneal ceftriaxone administration in healthy horses results in high and prolonged peritoneal concentrations. Recent findings suggest that intraperitoneal ceftriaxone might increase survival rates in horses affected by peritonitis. The present study aimed to evaluate plasma and peritoneal concentrations of ceftriaxone after intraperitoneal administration in horses with septic peritonitis. Twenty-six horses presenting clinical, laboratorial, and sonographic findings compatible with the disease were included. All horses received daily intraperitoneal ceftriaxone (25 mg/kg bwt) in addition or not with other antibiotics and support therapies. High-performance liquid chromatography was used to determine plasma and peritoneal ceftriaxone concentrations before and after 12 and 24 hours of ceftriaxone administration. Mean plasma concentrations 12 and 24 hours after administration were, respectively, 1.84 ± 0.43 and 0.37 ± 0.07 μg/mL, and mean peritoneal concentrations were 5.7 ± 2.84 and 0.42 ± 0.13 μg/mL. Ceftriaxone concentration was lower in comparison with previous studies in healthy horses and presented under the minimal inhibitory concentration for enterobacteria (≤1 μg/mL) and for gram-positive isolates (≤0.5 μg/mL) at 24 hours. The variation of the results obtained between healthy horses and with septic peritonitis demonstrated that pharmacokinetics/dynamics are different between these patients and suggests the use of an interval of dose of 12 hours.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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