Homeopathy in Experimental Cancer Models: A Systematic Review.
| Autor: | Dos Santos AP; Research Center, Universidade Paulista, UNIP, Graduate Program in Environmental and Experimental Pathology, São Paulo, Brazil., Cardoso TN; Research Center, Universidade Paulista, UNIP, Graduate Program in Environmental and Experimental Pathology, São Paulo, Brazil., Waisse S; Pontifical Catholic University of São Paulo, PUC-SP, Graduate Program in History of Science, São Paulo, Brazil., Bonamin LV; Research Center, Universidade Paulista, UNIP, Graduate Program in Environmental and Experimental Pathology, São Paulo, Brazil. |
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| Jazyk: | angličtina |
| Zdroj: | Homeopathy : the journal of the Faculty of Homeopathy [Homeopathy] 2021 May; Vol. 110 (2), pp. 76-85. Date of Electronic Publication: 2020 Dec 21. |
| DOI: | 10.1055/s-0040-1716369 |
| Abstrakt: | Background: Complementary and alternative medicine, including homeopathy, is widely used to improve well-being among cancer patients and reduce adverse effects of conventional treatment. In contrast, there are few studies on the use of homeopathic medicines to treat the disease itself. Yet, evidence of possible effectiveness of homeopathic high dilutions in experimental cancer models has been published during the past 20 years. Aim: The aim of the study was to perform a systematic review of fundamental research studies on homeopathic high dilutions in cancer. Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline, we conducted a literature search in the database PubMed for original publications, from 2000 to 2018 and in English, on in vitro and in vivo experimental cancer models testing homeopathic high dilutions. Results: Twenty-three articles met the inclusion criteria-14 in vitro , eight in vivo , and one in vitro plus in vivo experimental models. Most studies were from India. Research prominently focused on cytotoxic effects involving apoptotic mechanisms. Intrinsic aspects of homeopathy should be considered in experimental designs to emphasize the specificity of such effects. Conclusion: Fundamental research of homeopathy in cancer is still at an early stage and has mainly been performed by a few groups of investigators. The results point to an interference of well-selected homeopathic medicines with cell cycle and apoptotic mechanisms in cancer cells. However, these findings still need independent reproduction. Competing Interests: None declared. (Faculty of Homeopathy. This article is published by Thieme.) |
| Databáze: | MEDLINE |
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