Silent hypoxaemia in COVID-19 patients.

Autor: Simonson TS; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, University of California, San Diego, CA, USA., Baker TL; Department of Comparative Biosciences, University of Wisconsin -, Madison, WI, USA., Banzett RB; Division of Pulmonary, Critical Care, & Sleep Medicine Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA, USA., Bishop T; Target Discovery Institute, University of Oxford, Oxford, UK., Dempsey JA; Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin -, Madison, WI, USA., Feldman JL; Department of Neurobiology, University of California, Los Angeles, CA, USA., Guyenet PG; Department of Pharmacology, School of Medicine, University of Virginia, Charlottesville, VA, USA., Hodson EJ; The Francis Crick Institute, London, UK.; The Department of Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, UK., Mitchell GS; Department of Physical Therapy, Center for Respiratory Research and Rehabilitation, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA., Moya EA; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, University of California, San Diego, CA, USA., Nokes BT; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, University of California, San Diego, CA, USA., Orr JE; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, University of California, San Diego, CA, USA., Owens RL; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, University of California, San Diego, CA, USA., Poulin M; Departments of Physiology & Pharmacology and Clinical Neurosciences, Cumming School of Medicine and Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada., Rawling JM; Departments of Family Medicine, University of Calgary, Calgary, Alberta, Canada., Schmickl CN; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, University of California, San Diego, CA, USA., Watters JJ; Department of Comparative Biosciences, University of Wisconsin -, Madison, WI, USA., Younes M; Sleep Disorders Centre, University of Manitoba, Winnipeg, Manitoba, Canada., Malhotra A; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, University of California, San Diego, CA, USA.
Jazyk: angličtina
Zdroj: The Journal of physiology [J Physiol] 2021 Feb; Vol. 599 (4), pp. 1057-1065. Date of Electronic Publication: 2021 Jan 04.
DOI: 10.1113/JP280769
Abstrakt: The clinical presentation of COVID-19 due to infection with SARS-CoV-2 is highly variable with the majority of patients having mild symptoms while others develop severe respiratory failure. The reason for this variability is unclear but is in critical need of investigation. Some COVID-19 patients have been labelled with 'happy hypoxia', in which patient complaints of dyspnoea and observable signs of respiratory distress are reported to be absent. Based on ongoing debate, we highlight key respiratory and neurological components that could underlie variation in the presentation of silent hypoxaemia and define priorities for subsequent investigation.
(© 2020 The Authors. The Journal of Physiology © 2020 The Physiological Society.)
Databáze: MEDLINE
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