| Autor: |
Pastushkova LH; Institute of Biomedical Problems of RAS, 76 a Khoroszewskoe shosse, Moscow 123007, Russian Federation, e-mail: goncharova.anna@gmail.com., Kashirina DN; Institute of Biomedical Problems of RAS, 76 a Khoroszewskoe shosse, Moscow 123007, Russian Federation, e-mail: goncharova.anna@gmail.com., Goncharova AG; Institute of Biomedical Problems of RAS, 76 a Khoroszewskoe shosse, Moscow 123007, Russian Federation, e-mail: goncharova.anna@gmail.com., Zakharova NB; V.I.Razumovsky Saratov State Medical University, 112 Bolshaya Kazachya str., Saratov 410012, Russian Federation., Tiys ES; Federal Research Center institute of Cytology and Genetics of SO RAS, 10 akad. Lavrentiev pr., Novosibirsk 630090, Russian Federation., Goncharov IN; Institute of Biomedical Problems of RAS, 76 a Khoroszewskoe shosse, Moscow 123007, Russian Federation, e-mail: goncharova.anna@gmail.com., Larina IM; Institute of Biomedical Problems of RAS, 76 a Khoroszewskoe shosse, Moscow 123007, Russian Federation, e-mail: goncharova.anna@gmail.com. |
| Abstrakt: |
For the first time proteins are described, reliably increasing and decreasing in urine with age in the range of 20 to 60 years. The combinations of proteins associated with changes in immune processes, violation of blood reology, including the risk of coagulopathy, anticancer defense mechanisms, insulin signaling pathway, changes in cell characteristics are characterized division and quality of the newly formed fabric. Thus, the age dynamics of the main processes triggers a cascade of reactions manifested in the closure of «pathological biochemical circles» that form the prerequisites for the development of diseases and, over time, clinical manifestations. |
