| Autor: |
Gizinger OA; Peoples' Friendship University of Russia, Medical Institute, 6 Miklukho-Maklaya str., Moscow 117049, Russian Federation, e-mail: ogizinger@gmail.com., Dolgova VI; South Ural State University for the Humanities and Education, 69 pr. V.I.Lenina, Chelyabinsk 454080, Russian Federation., Mamylina NV; South Ural State University for the Humanities and Education, 69 pr. V.I.Lenina, Chelyabinsk 454080, Russian Federation. |
| Jazyk: |
ruština |
| Zdroj: |
Advances in gerontology = Uspekhi gerontologii [Adv Gerontol] 2020; Vol. 33 (4), pp. 695-702. |
| Abstrakt: |
The study included 50 women aged 60±1,5 years, teaching for 30±5,5 years at the middle level of a secondary school (grades 5-9) - main group, and 50 non-working women 61,5±1,3 years. The purpose of the study was to study the role of vitamin D in the formation of immunopathogenetic changes from cellular and humoral immune factors, free radical oxidation processes in working teachers and unemployed elderly women and the possibility of correcting the revealed violations with vitamin D subsidy. Before the start of the study, a decrease in the total content of vitamin D was revealed, violation of the functional and metabolic status of immunocytes, an imbalance in the production of Th1/Th2 cytokines, an increase in primary and secondary products peroxidation of the lipid extract of blood plasma, a decrease in the activity of superoxide dismutase and catalase to the main and control groups. The presence of direct correlations between the content of vitamin D, the balance of cytokines, the components of the lipid peroxidation system and antioxidant defense is proved. A vitamin D subsidy reduced the severity of immune and oxidative disorders in subjects. The obtained results confirm the need for monitoring the vitamin D content in order to reduce the risk of developing immunopathogenetic disorders in the elderly. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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