Molecular mechanisms of anticancer activities of polyphyllin VII.

Autor: Ahmad B; Department of Biology (Botany, Zoology, Biochemistry), The University of Haripur, Haripur, Pakistan.; College of Basic Medical Sciences, Dalian Medical University, Dalian, China., Rehman SU; Department of Biology (Botany, Zoology, Biochemistry), The University of Haripur, Haripur, Pakistan., Azizullah A; Department of Biology (Botany, Zoology, Biochemistry), The University of Haripur, Haripur, Pakistan., Khan MF; Zoology Department, Hazara University, Mansehra, Pakistan., Din SRU; College of Basic Medical Sciences, Dalian Medical University, Dalian, China., Ahmad M; Department of Chemistry, Malakand University, Chakdara, Pakistan., Ali A; Department of Chemistry, The University of Haripur, Haripur, Pakistan., Tahir N; College of Basic Medical Sciences, Dalian Medical University, Dalian, China., Azam N; College of Basic Medical Sciences, Dalian Medical University, Dalian, China., Gamallat Y; Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou, China., Rahman KU; College of Basic Medical Sciences, Dalian Medical University, Dalian, China., Ali M; College of Basic Medical Sciences, Dalian Medical University, Dalian, China., Safi M; Oncology Department First affiliated Hospital of Dalian Medical University, Dalian, China., Khan I; Department of Food Science and Technology, The University of Haripur, Haripur, Pakistan., Qamer S; Department of Zoology, Government College University Faisalabad, Faisalabad, Pakistan., Oh DH; Department of Food Science and Biotechnology, Kangwon National University, Chuncheon, South Korea.
Jazyk: angličtina
Zdroj: Chemical biology & drug design [Chem Biol Drug Des] 2021 Apr; Vol. 97 (4), pp. 914-929. Date of Electronic Publication: 2021 Jan 07.
DOI: 10.1111/cbdd.13818
Abstrakt: Cancer is the leading cause of mortality in the world. The major therapies for cancer treatment are chemotherapy, surgery, and radiation therapy. All these therapies expensive, toxic and show resistance. The plant-derived compounds are considered safe, cost-effective and target cancer through different pathways. In these pathways include oxidative stress, mitochondrial dependent and independent, STAT3, NF-kB, MAPKs, cell cycle, and autophagy pathways. One of the new plants derived compounds is Polyphyllin VII (PPVII), which target cancer through different molecular mechanisms. In literature, there is a review gap of studies on PPVII; therefore in the current review, we summarized the available studies on PPVII to provide a base for future research.
(© 2020 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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