Preparation of glass-ionomer cement containing ethanolic Brazilian pepper extract (Schinus terebinthifolius Raddi) fruits: chemical and biological assays.

Autor: Pinto IC; Departamento de Química, Universidade Federal de Ouro Preto, UFOP, Ouro Preto, 35400-000, Brazil., Seibert JB; Departamento de Química, Universidade Federal de São Carlos, UFSCar, São Carlos, 13565-905, Brazil., Pinto LS; Departamento de Química, Universidade Federal de São Carlos, UFSCar, São Carlos, 13565-905, Brazil., Santos VR; Departamento de Clínica, Patologia e Cirurgias Odontológicas, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte, 31270-901, Brazil., de Sousa RF; Departamento de Química, Universidade Federal de Ouro Preto, UFOP, Ouro Preto, 35400-000, Brazil., Sousa LRD; Departamento de Química, Universidade Federal de Ouro Preto, UFOP, Ouro Preto, 35400-000, Brazil.; Departamento de Ciências Biológicas, Universidade Federal de Ouro Preto, UFOP, Ouro Preto, 35400-000, Brazil., Amparo TR; Laboratório de Fitotecnologia, Universidade Federal de Ouro Preto, UFOP, Ouro Preto, 35400-000, Brazil., Dos Santos VMR; Departamento de Química, Universidade Federal de Ouro Preto, UFOP, Ouro Preto, 35400-000, Brazil., do Nascimento AM; Departamento de Química, Universidade Federal de Ouro Preto, UFOP, Ouro Preto, 35400-000, Brazil., de Souza GHB; Laboratório de Fitotecnologia, Universidade Federal de Ouro Preto, UFOP, Ouro Preto, 35400-000, Brazil., Vasconcellos WA; Departamento de Odontologia Restauradora, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte, 31270-901, Brazil., Vieira PMA; Departamento de Ciências Biológicas, Universidade Federal de Ouro Preto, UFOP, Ouro Preto, 35400-000, Brazil., Andrade ÂL; Departamento de Química, Universidade Federal de Ouro Preto, UFOP, Ouro Preto, 35400-000, Brazil. angelaleao@ufop.edu.br.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2020 Dec 18; Vol. 10 (1), pp. 22312. Date of Electronic Publication: 2020 Dec 18.
DOI: 10.1038/s41598-020-79257-3
Abstrakt: Plants may contain beneficial or potentially dangerous substances to humans. This study aimed to prepare and evaluate a new drug delivery system based on a glass-ionomer-Brazilian pepper extract composite, to check for its activity against pathogenic microorganisms of the oral cavity, along with its in vitro biocompatibility. The ethanolic Brazilian pepper extract (BPE), the glass-ionomer cement (GIC) and the composite GIC-BPE were characterized by scanning electron microscopy, attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), and thermal analysis. The BPE compounds were identified by UPLC-QTOF-MS/MS. The release profile of flavonoids and the mechanical properties of the GIC-BPE composite were assessed. The flavonoids were released through a linear mechanism governing the diffusion for the first 48 h, as evidenced by the M t /M ∞ relatively to [Formula: see text], at a diffusion coefficient of 1.406 × 10 -6  cm 2  s -1 . The ATR-FTIR analysis indicated that a chemical bond between the GIC and BPE components may have occurred, but the compressive strength of GIC-BPE does not differ significantly from that of this glass-ionomer. The GIC-BPE sample revealed an ample bacterial activity at non-cytotoxic concentrations for the human fibroblast MRC-5 cells. These results suggest that the prepared composite may represent an alternative agent for endodontic treatment.
Databáze: MEDLINE
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