Reactivation of Chagas disease after autologous hematopoietic stem cell transplantation.

Autor: Chalela CM; Universidad Autónoma de Bucaramanga, Faculty of Health Sciences, Bucaramanga, Santander, Colombia., Peña AM; Universidad Autónoma de Bucaramanga, Faculty of Health Sciences, Bucaramanga, Santander, Colombia.; Clínica FOSCAL, Hematopoietic and Stem Cell Transplantation Unit, Floridablanca, Santander, Colombia., Roa AM; Universidad Autónoma de Bucaramanga, Faculty of Health Sciences, Bucaramanga, Santander, Colombia., Reyes DL; Universidad Autónoma de Bucaramanga, Faculty of Health Sciences, Bucaramanga, Santander, Colombia., Rueda JP; Universidad Autónoma de Bucaramanga, Faculty of Health Sciences, Bucaramanga, Santander, Colombia., Salazar LA; Universidad Autónoma de Bucaramanga, Faculty of Health Sciences, Bucaramanga, Santander, Colombia.; Clínica FOSCAL, Hematopoietic and Stem Cell Transplantation Unit, Floridablanca, Santander, Colombia., Rosales M; Clínica FOSCAL, Hematopoietic and Stem Cell Transplantation Unit, Floridablanca, Santander, Colombia., Gomez ED; Universidad Autónoma de Bucaramanga, Faculty of Health Sciences, Bucaramanga, Santander, Colombia.; Clínica FOSCAL, Department of Internal Medicine, Floridablanca, Santander, Colombia., Bernal EA; Clínica FOSCAL, Department of Infectious Diseases, Floridablanca, Santander, Colombia., Melo CLS; Universidad Autónoma de Bucaramanga, Faculty of Health Sciences, Bucaramanga, Santander, Colombia.; Clínica FOSCAL, Hematopoietic and Stem Cell Transplantation Unit, Floridablanca, Santander, Colombia.
Jazyk: angličtina
Zdroj: Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2020 Dec 21; Vol. 54, pp. e20200143. Date of Electronic Publication: 2020 Dec 21 (Print Publication: 2020).
DOI: 10.1590/0037-8682-0143-2020
Abstrakt: Chagas disease (CD) is a protozoan zoonosis caused by Trypanosoma cruzi. Reactivation of CD occurs via drug-induced immunosuppression before and during transplantation. Here, we report the case of a 62-year-old man diagnosed with classic Hodgkin lymphoma who received highly aggressive conditioning chemotherapy before undergoing stem cell transplantation (SCT). The patient tested positive for CD in pre-transplantation evaluation. The patient exhibited persistent fever and elevated C-reactive protein levels before and after SCT, and was treated with antibiotics. Micro-Strout test showed evidence of trypomastigotes and he was treated with benznidazole until tested negative. Post-transplantation seropositive patients should be screened for possible reactivation.
Databáze: MEDLINE
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