| Autor: |
da Silva FC; Department of Biological Sciences, São Lucas Ji-Paraná University Center (UniSL), Ji-Paraná, Brazil.; Department of Post-Graduation Program in Molecular and Cell Biology Applied to Health, Lutheran University of Brazil (ULBRA), Canoas, Brazil., de Souza AH; Department of Post-Graduation Program in Molecular and Cell Biology Applied to Health, Lutheran University of Brazil (ULBRA), Canoas, Brazil., Bassoli BK; Department of Medicine, Federal University of Roraima (UFRR), Boa Vista, Brazil., Prates GA; Department of Biological Sciences, São Lucas Ji-Paraná University Center (UniSL), Ji-Paraná, Brazil., Daudt C; Center of Natural and Biological Sciences, Federal University of Acre (UFAC), Rio Branco, Brazil., Meneguetti DUO; Laboratory of Physiopharmacology, Post-Graduation Program in Sciences of Health of Western Amazonia, Federal University of Acre (UFAC), Rio Branco, Brazil., Corrêa ÁP; Department of Pharmacy, Lutheran University of Brazil (ULBRA), Canoas, Brazil., de Oliveira IB; Department of Pharmacy, Lutheran University of Brazil (ULBRA), Canoas, Brazil., Schons SV; Department of Post-Graduation Program in Environmental Sciences, Federal University of Rondônia (UNIR), Rolim de Moura, Brazil., Fialho MFP; Department of Post-Graduation Program in Biological Sciences: Toxicological Biochemistry, Federal University of Santa Maria, Santa Maria, Brazil., Correa DS; Department of Post-Graduation Program in Molecular and Cell Biology Applied to Health, Lutheran University of Brazil (ULBRA), Canoas, Brazil., Picada JN; Department of Post-Graduation Program in Molecular and Cell Biology Applied to Health, Lutheran University of Brazil (ULBRA), Canoas, Brazil., Ferraz ABF; Department of Post-Graduation Program in Molecular and Cell Biology Applied to Health, Lutheran University of Brazil (ULBRA), Canoas, Brazil. |
| Abstrakt: |
The Myrciaria dubia (Myrtaceae) fruit is traditionally used to treat malnutrition due to its high levels of vitamin C and phenolic compounds. Because of its composition, this plant is very promising in the research of novel natural treatment for pain disorders. This study analyzed the phytochemical profile of M. dubia juice and assessed its antinociceptive and antiedematogenic potential. The phytochemical profile was determined through high-performance liquid chromatography (HPLC), the oral antinociceptive effect of M. dubia 50% juice (Md50) was evaluated by formalin, hot plate and Complete Freund's Adjuvant tests and the antiedematogenic activity by paw edema. HPLC revealed the presence of ascorbic acid, rutin, and ellagic acid as major compounds. Md50 showed an antinociceptive effect in the acute and chronic phases of the formalin test. In the hot plate test, Md50 also induced an antinociceptive effect of 0.5 up to 6 h, showing antinociceptive and antiedematogenic potential without changing the spontaneous locomotion of animals. All protocols were submitted and approved by the Ethics Committee for use of Animals of the Lutheran University of Brazil (protocol No. 2013-30P). |
