Vaccine Effectiveness Against Influenza-Associated Hospitalizations Among Adults, 2018-2019, US Hospitalized Adult Influenza Vaccine Effectiveness Network.

Autor:	Ferdinands JM; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Gaglani M; Baylor Scott & White Health System, Temple, Texas, USA., Ghamande S; Baylor Scott & White Health System, Temple, Texas, USA., Martin ET; University of Michigan School of Public Health, Ann Arbor, Michigan, USA., Middleton D; University of Pittsburgh Medical Center; Pittsburgh, Pennsylvania, USA., Monto AS; University of Michigan School of Public Health, Ann Arbor, Michigan, USA., Silveira F; University of Pittsburgh Medical Center; Pittsburgh, Pennsylvania, USA., Talbot HK; Vanderbilt University Medical Center, Nashville, Tennessee, USA., Zimmerman R; University of Pittsburgh Medical Center; Pittsburgh, Pennsylvania, USA., Smith ER; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Patel M; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2021 Jul 02; Vol. 224 (1), pp. 151-163.
DOI:	10.1093/infdis/jiaa772
Abstrakt:	We estimated vaccine effectiveness (VE) for prevention of influenza-associated hospitalizations among adults during the 2018-2019 influenza season. Adults admitted with acute respiratory illness to 14 hospitals of the US Hospitalized Adult Influenza Vaccine Effectiveness Network (HAIVEN) and testing positive for influenza were cases; patients testing negative were controls. VE was estimated using logistic regression and inverse probability of treatment weighting. We analyzed data from 2863 patients with a mean age of 63 years. Adjusted VE against influenza A(H1N1)pdm09-associated hospitalization was 51% (95% confidence interval [CI], 25%-68%). Adjusted VE against influenza A(H3N2) virus-associated hospitalization was -2% (95% CI, -65% to 37%) and differed significantly by age, with VE of -130% (95% CI, -374% to -27%) among adults 18 to ≤56 years of age. Although vaccination halved the risk of influenza A(H1N1)pdm09-associated hospitalizations, it conferred no protection against influenza A(H3N2)-associated hospitalizations. We observed negative VE for young and middle-aged adults but cannot exclude residual confounding as a potential explanation. (Published by Oxford University Press for the Infectious Diseases Society of America 2020.)
Databáze:	MEDLINE
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