Prognostic relevance of adding MRI data to WHO 2016 and cIMPACT-NOW updates for diffuse astrocytic tumors in adults. Working toward the extended use of MRI data in integrated glioma diagnosis.

Autor:	Roux A; Service de Neurochirurgie, GHU Paris-Psychiatrie et Neurosciences-Hôpital Sainte-Anne, Paris, France.; Université de Paris, Sorbonne Paris Cité, Paris, France.; Inserm, UMR1266, IMA-Brain, Institut de Psychiatrie et Neurosciences de Paris, Paris, France., Tran S; Service de Neuropathologie, GHU Paris-Psychiatrie et Neurosciences-Hôpital Sainte-Anne, Paris, France., Edjlali M; Université de Paris, Sorbonne Paris Cité, Paris, France.; Inserm, UMR1266, IMA-Brain, Institut de Psychiatrie et Neurosciences de Paris, Paris, France.; Service de Neuroradiologie, GHU Paris-Psychiatrie et Neurosciences-Hôpital Sainte-Anne, Paris, France., Saffroy R; Service de Biochimie, Hôpital Paul-Brousse, AP-HP, Villejuif, France., Tauziede-Espariat A; Université de Paris, Sorbonne Paris Cité, Paris, France.; Inserm, UMR1266, IMA-Brain, Institut de Psychiatrie et Neurosciences de Paris, Paris, France.; Service de Neuropathologie, GHU Paris-Psychiatrie et Neurosciences-Hôpital Sainte-Anne, Paris, France., Zanello M; Service de Neurochirurgie, GHU Paris-Psychiatrie et Neurosciences-Hôpital Sainte-Anne, Paris, France.; Université de Paris, Sorbonne Paris Cité, Paris, France.; Inserm, UMR1266, IMA-Brain, Institut de Psychiatrie et Neurosciences de Paris, Paris, France., Gareton A; Université de Paris, Sorbonne Paris Cité, Paris, France.; Service de Neuropathologie, GHU Paris-Psychiatrie et Neurosciences-Hôpital Sainte-Anne, Paris, France., Dezamis E; Service de Neurochirurgie, GHU Paris-Psychiatrie et Neurosciences-Hôpital Sainte-Anne, Paris, France.; Université de Paris, Sorbonne Paris Cité, Paris, France.; Inserm, UMR1266, IMA-Brain, Institut de Psychiatrie et Neurosciences de Paris, Paris, France., Dhermain F; Département d'Oncologie Radiothérapie, Gustave Roussy Cancer Campus Grand Paris, Villejuif, France., Chretien F; Université de Paris, Sorbonne Paris Cité, Paris, France.; Inserm, UMR1266, IMA-Brain, Institut de Psychiatrie et Neurosciences de Paris, Paris, France.; Service de Neuropathologie, GHU Paris-Psychiatrie et Neurosciences-Hôpital Sainte-Anne, Paris, France., Lechapt-Zalcman E; Université de Paris, Sorbonne Paris Cité, Paris, France.; Inserm, UMR1266, IMA-Brain, Institut de Psychiatrie et Neurosciences de Paris, Paris, France.; Service de Neuropathologie, GHU Paris-Psychiatrie et Neurosciences-Hôpital Sainte-Anne, Paris, France., Oppenheim C; Université de Paris, Sorbonne Paris Cité, Paris, France.; Inserm, UMR1266, IMA-Brain, Institut de Psychiatrie et Neurosciences de Paris, Paris, France.; Service de Neuroradiologie, GHU Paris-Psychiatrie et Neurosciences-Hôpital Sainte-Anne, Paris, France., Pallud J; Service de Neurochirurgie, GHU Paris-Psychiatrie et Neurosciences-Hôpital Sainte-Anne, Paris, France.; Université de Paris, Sorbonne Paris Cité, Paris, France.; Inserm, UMR1266, IMA-Brain, Institut de Psychiatrie et Neurosciences de Paris, Paris, France., Varlet P; Université de Paris, Sorbonne Paris Cité, Paris, France.; Inserm, UMR1266, IMA-Brain, Institut de Psychiatrie et Neurosciences de Paris, Paris, France.; Service de Neuropathologie, GHU Paris-Psychiatrie et Neurosciences-Hôpital Sainte-Anne, Paris, France.
Jazyk:	angličtina
Zdroj:	Brain pathology (Zurich, Switzerland) [Brain Pathol] 2021 Jul; Vol. 31 (4), pp. e12929. Date of Electronic Publication: 2021 Feb 15.
DOI:	10.1111/bpa.12929
Abstrakt:	Assess the contribution of preoperative MRI data in improving grading of adult astrocytomas reclassified according to the WHO 2016 and cIMPACT-NOW update 3. Retrospective unicentric cohort study of 679 adult patients treated for newly diagnosed diffuse astrocytic and oligodendroglial tumors (January 2006-December 2016). We first systematically compared radiological (contrast enhancement present [CE+] vs. absent [CE-]) and histopathological findings (microvascular proliferation present [MPV+] vs. absent [MPV-]) to validate whether this comparing step of neoangiogenesis represents an efficient method to appreciate the representativity of the tumoral sampling. We focused on 629 cases of astrocytomas for radio-histological integrated analyses. In 598 cases (95.1%), neoangiogenesis evaluated by MRI or histology (CE+/MPV+ or CE-/MPV-) was identical. For the CE+/MPV- and CE-/MPV+ groups (23 cases), the radio-histological face-to-face evaluation allowed us to assess that for 13 cases (56.5%) the reason for this discrepancy was an undersampled tumor. We analyzed the group of CE+/MPV- (n = 8) and CE-/MPV+ (n = 2) in verified image-guided tumoral samples. Finally, we identified three new prognostic subgroups for molecular glioblastomas: (1) "non-representative sampling" (n = 9), (2) "Non neoangiogenic glioblastoma at the time of diagnosis, without contrast enhancement and microvascular proliferation" (n = 8), and (3) "contrast enhancing glioblastoma but without microvascular proliferation in a representative sample" (n = 4). Neoangiogenesis processes should be assessed to improve the prognosis accuracy of the current integrated diagnosis. We suggest adding imaging analyses during the neuropathological analysis of astrocytomas in adults. (© 2020 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology.)
Databáze:	MEDLINE
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