Conditioned pain modulation-A comprehensive review.

Autor: Ramaswamy S; 1St Bartholomew's Hospital, Bart's Health NHS Trust, London, EC1A 4AS, UK. Electronic address: Shankar.ramaswamy@nhs.net., Wodehouse T; 1St Bartholomew's Hospital, Bart's Health NHS Trust, London, EC1A 4AS, UK.
Jazyk: angličtina
Zdroj: Neurophysiologie clinique = Clinical neurophysiology [Neurophysiol Clin] 2021 Jun; Vol. 51 (3), pp. 197-208. Date of Electronic Publication: 2020 Dec 14.
DOI: 10.1016/j.neucli.2020.11.002
Abstrakt: Conditioned pain modulation (CPM) is a centrally processed measure of the net effect of the descending pain pathway. This comprises both the facilitatory as well as the inhibitory effect. In the past, CPM or similar effects have been previously described using different terminologies such as diffuse noxious inhibitory control (DNIC), heterotopic noxious conditioning stimulation (HNCS) or endogenous analgesia (EA). A variety of patient-related factors such as age, gender, hormones, race, genetic and psychological factors have been thought to influence the CPM paradigms. CPM paradigms have also been associated with a wide range of methodological variables including the mode of application of the 'test' as well as the 'conditioning' stimuli. Despite all these variabilities, CPM seems to reliably lend itself to the pain modulation profile concept and could in future become one of the phenotypic biomarkers for pain and also a guide for mechanism-based treatment in chronic pain. Future research should focus on establishing consistent methodologies for measuring CPM and thereby enhancing the robustness of this emerging biomarker for pain.
(Crown Copyright © 2020. Published by Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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