A rare case of late-onset ticagrelor-induced sinus arrest.

Autor:	Aranganathan P; Department of Cardiology, G. Kuppuswamy Naidu Memorial Hospital, Coimbatore, India., Wilson B; Department of Cardiology, G. Kuppuswamy Naidu Memorial Hospital, Coimbatore, India., Rangan A; Department of Cardiology, G. Kuppuswamy Naidu Memorial Hospital, Coimbatore, India., Boopathi A; Department of Cardiology, G. Kuppuswamy Naidu Memorial Hospital, Coimbatore, India., Balasundaram R; Department of Cardiology, G. Kuppuswamy Naidu Memorial Hospital, Coimbatore, India.
Jazyk:	angličtina
Zdroj:	Asian cardiovascular & thoracic annals [Asian Cardiovasc Thorac Ann] 2021 Nov; Vol. 29 (9), pp. 946-949. Date of Electronic Publication: 2020 Dec 17.
DOI:	10.1177/0218492320981483
Abstrakt:	Ticagrelor is a potent reversible P2Y12 inhibitor with proven superiority over clopidogrel. Ticagrelor increases the tissue concentration of adenosine, thereby leading to bradyarrhythmia. This complication is reported to occur very early after initiating the drug. A randomized controlled trial reported that ticagrelor-induced pauses have an early onset without much clinical impact. However, our patient developed ticagrelor-induced hemodynamically significant sinus arrest 10 months after coronary artery stenting, which improved after stopping the drug. Ticagrelor should be considered as one of the uncommon reasons for late-onset sinus pause or bradyarrhythmia.
Databáze:	MEDLINE
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