Bone loss in patients with inflammatory bowel disease: cause, detection and treatment.
| Autor: | Bravenboer N; Department of Clinical Chemistry, Amsterdam UMC, Location Vrije Universiteit, Research Institute Amsterdam Movement Sciences, Amsterdam., Oostlander AE; Department of Clinical Chemistry, Amsterdam UMC, Location Vrije Universiteit, Research Institute Amsterdam Movement Sciences, Amsterdam., van Bodegraven AA; Department of Gastroenterology, Geriatrics, Internal and Intensive Care Medicine (Co-MIK), Zuyderland MC, Sittard-Geleen-Heerlen; Department of Gastroenterology, Amsterdam UMC, Location Vrije Universiteit, the Netherlands. |
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| Jazyk: | angličtina |
| Zdroj: | Current opinion in gastroenterology [Curr Opin Gastroenterol] 2021 Mar 01; Vol. 37 (2), pp. 128-134. |
| DOI: | 10.1097/MOG.0000000000000710 |
| Abstrakt: | Purpose of Review: Inflammatory bowel disease (IBD) is associated with bone loss leading to osteoporosis and increased fracture risk. Bone loss is the result of changes in the balanced process of bone remodeling. Immune cells and cytokines play an important role in the process of bone remodeling and it is therefore not surprising that cytokines as observed in IBD are involved in bone pathology. This review discusses the role of cytokines in IBD-associated bone loss, including the consequences for treatment. Recent Findings: Many studies have been conducted that showed the effect of a single cytokine on bone cells in vitro, including interleukin (IL)-1β, IL-6, IL-8, IL-12/IL-23, IL-17, IL-18, IL-32 and interferon-γ. Recently new members of the IL-1 family (IL-1F) have been related to IBD but the consequences for bone health remain uncertain. Summary: Overall, patients have to deal with a cocktail of cytokines, present in their serum. The combination of cytokines can affect bone cells differently compared to the effects of a single cytokine. This implicates that treatment, focused on reducing the inflammation could work best for bone health as well. Vitamin D might also play a role in this. (Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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