Novel therapeutic regimens for urethane-induced early lung cancer in rats: Combined cisplatin nanoparticles with vitamin-D 3 .

Autor: Radwan E; Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt., Ali M; Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt., Faied SMA; Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt., Omar HM; Department of Zoology, Faculty of Science, Assiut University, Assiut, Egypt., Mohamed WS; Department of Polymers and Pigments, National Research Centre, Giza, Egypt., Abd-Elghaffar SK; Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt., Sayed AA; Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt.
Jazyk: angličtina
Zdroj: IUBMB life [IUBMB Life] 2021 Feb; Vol. 73 (2), pp. 362-374. Date of Electronic Publication: 2020 Dec 17.
DOI: 10.1002/iub.2432
Abstrakt: Lung cancer remains incurable; therefore, novel therapeutical approaches are of great demand. This study was designed to investigate the effectiveness of cisplatin nanoparticles combined with vitamin-D 3 on urethane-induced early lung cancer in rats and to clarify the underlying signaling mechanisms. Early lung cancer was induced in male Wistar rats by urethane. Rats were divided into six groups: I-control, II-cancer untreated, III-cancer + free cisplatin, IV-cancer + cisplatin nanoparticles, V-cancer + free cisplatin + vitamin-D 3 , VI-cancer + cisplatin nanoparticles + vitamin-D 3 . Inflammation, proliferation, and apoptosis were evaluated together with the levels of tumor marker CK-19 along with histological assessment. Treatment of lung cancer with either free or nanoparticles of cisplatin alone demonstrated significant suppression in the expression of inflammatory, anti-apoptotic and tumor markers compared to rats with lung cancer. Moreover, vitamin-D 3 supplementation with either cisplatin forms lead to a further decrease of all markers, markedly with cisplatin nanoparticles. The present study shows the synergistic effect of cisplatin-nanoparticles combined with vitamin-D 3 as a new therapy regimen against lung cancer. Further studies with larger sample sizes and longer duration are needed to confirm these results.
(© 2020 International Union of Biochemistry and Molecular Biology.)
Databáze: MEDLINE
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