New sesquiterpeniod esters form Blumea balsamifera (L.) DC. and their anti-influenza virus activity.

Autor: Xiong Y; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou medical university, Guiyang, China.; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and, Chinese Academy of Sciences, Guiyang, China.; Guizhou Nursing Vocational College, Guiyang, China., Yi P; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou medical university, Guiyang, China.; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and, Chinese Academy of Sciences, Guiyang, China., Li Y; Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences, Beijing, China., Gao R; Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences, Beijing, China., Chen J; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou medical university, Guiyang, China.; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and, Chinese Academy of Sciences, Guiyang, China., Hu Z; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou medical university, Guiyang, China.; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and, Chinese Academy of Sciences, Guiyang, China., Lou H; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou medical university, Guiyang, China.; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and, Chinese Academy of Sciences, Guiyang, China., Du C; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou medical university, Guiyang, China.; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and, Chinese Academy of Sciences, Guiyang, China., Zhang J; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou medical university, Guiyang, China.; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and, Chinese Academy of Sciences, Guiyang, China., Zhang Y; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming institute of Botany, Chinese Academy of Sciences, Kunming, China., Yuan C; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou medical university, Guiyang, China.; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and, Chinese Academy of Sciences, Guiyang, China., Huang L; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou medical university, Guiyang, China.; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and, Chinese Academy of Sciences, Guiyang, China., Hao X; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou medical university, Guiyang, China.; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and, Chinese Academy of Sciences, Guiyang, China.; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming institute of Botany, Chinese Academy of Sciences, Kunming, China., Gu W; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou medical university, Guiyang, China.; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and, Chinese Academy of Sciences, Guiyang, China.
Jazyk: angličtina
Zdroj: Natural product research [Nat Prod Res] 2022 Mar; Vol. 36 (5), pp. 1151-1160. Date of Electronic Publication: 2020 Dec 17.
DOI: 10.1080/14786419.2020.1861615
Abstrakt: Phytochemical studies led to the isolation of five new sesquiterpeniod esters, named balsamiferine N-R, along with ten known compounds (6-15) from the leaves of Blumea balsamifera (L.) DC. The skeletons of nine known sesquiterpeniods belong to guaiane and eudesmane. The structures of the new compounds including their absolute configurations were elucidated by comprehensive spectroscopic analysis, and quantum-chemical electronic circular dichroism (ECD) calculation. Compounds 3 and 4 showed significant inhibitory effects on influenza A virus (H3N2) with IC 50 values of 46.23 μg/mL and 38.49 μg/mL, respectively. It was the first report on the anti-influenza A virus constituents from B. balsamifera .
Databáze: MEDLINE