Pharmacokinetics and Tissue Levels of Pantoprazole in Neonatal Calves After Intravenous Administration.
Autor: | Olivarez JD; Lloyd Veterinary Medical Center, College of Veterinary Medicine, Iowa State University, Ames, IA, United States., Kreuder AJ; Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, United States., Tatarniuk DM; Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, United States., Wulf LW; Analytical Chemistry Services, College of Veterinary Medicine, Iowa State University, Ames, IA, United States., Dembek KA; Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, United States., Mochel JP; Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, United States.; Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, United States., Smith JS; Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, United States.; Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, United States. |
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Jazyk: | angličtina |
Zdroj: | Frontiers in veterinary science [Front Vet Sci] 2020 Nov 27; Vol. 7, pp. 580735. Date of Electronic Publication: 2020 Nov 27 (Print Publication: 2020). |
DOI: | 10.3389/fvets.2020.580735 |
Abstrakt: | Background: Neonatal calves are at risk of developing abomasal ulceration, but there is a lack of pharmacokinetic data for potential anti-ulcerative therapies, such as pantoprazole, in ruminant species. Objective: The study objectives were to estimate plasma pharmacokinetic parameters for pantoprazole in neonatal dairy calves after intravenous (IV) administration. A secondary objective was to quantify the concentrations of pantoprazole in edible tissues after IV dosing. Methods: Pantoprazole was administered to 9 neonatal Holstein calves at a dose of 1 mg/kg IV. Plasma samples were collected over 24 h and analyzed via HPLC-MS for determining pantoprazole concentrations. Pharmacokinetic parameters were derived via non-compartmental analysis. Tissue samples were collected at 1, 3, and 5 days after administration and analyzed via HPLC-MS. Results: Following IV administration, plasma clearance, elimination half-life, and volume of distribution of pantoprazole were estimated at 4.46 mL/kg/min, 2.81 h, and 0.301 L/kg, respectively. The global extraction ratio was estimated at 0.053 ± 0.015. No pantoprazole was detected in the edible tissues 1, 3, or 5 days after administration. A metabolite, pantoprazole sulfone was detected in all the edible tissues 1 and 3 days after administration. Conclusion: The reported plasma clearance for pantoprazole is less than that reported for alpacas but higher than reported in foals. The elimination half-life in calves appears to be longer than observed in foals and alpacas. While pantoprazole sulfone was detected in the tissues after IV administration, further research is needed as to the metabolism and potential tissue accumulation of other pantoprazole metabolites in calves. Future pharmacodynamic studies are necessary to determine the efficacy of pantoprazole on abomasal acid suppression in calves. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2020 Olivarez, Kreuder, Tatarniuk, Wulf, Dembek, Mochel and Smith.) |
Databáze: | MEDLINE |
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