Covid-19 and blood groups: ABO antibody levels may also matter.

Autor:	Deleers M; Department of Transfusion, CHU Brugmann, Université Libre de Bruxelles (ULB), Brussels, Belgium; Laboratory of Immunology, LHUB-ULB, Brussels, Belgium. Electronic address: Marie.deleers@chu-brugmann.be., Breiman A; Université de Nantes, INSERM, CRCINA, Nantes, France; CHU de Nantes, Nantes, France., Daubie V; Laboratory of Immunology, LHUB-ULB, Brussels, Belgium., Maggetto C; Department of Transfusion, CHU Brugmann, Université Libre de Bruxelles (ULB), Brussels, Belgium., Barreau I; Department of Transfusion, CHU Brugmann, Université Libre de Bruxelles (ULB), Brussels, Belgium; Laboratory of Immunology, LHUB-ULB, Brussels, Belgium., Besse T; Department of Clinical Research, CHU Brugmann, Université Libre de Bruxelles (ULB), Brussels, Belgium., Clémenceau B; Université de Nantes, INSERM, CRCINA, Nantes, France; CHU de Nantes, Nantes, France., Ruvoën-Clouet N; Université de Nantes, INSERM, CRCINA, Nantes, France; Oniris, Ecole Nationale Vétérinaire, Agroalimentaire et de l'Alimentation, Nantes, France., Fils JF; Ars Statistica, Boulevard des Archers 40, 1400, Nivelles, Belgium., Maillart E; Department of Infectious Diseases, CHU Brugmann, Université Libre de Bruxelles (ULB), Brussels, Belgium., Doyen V; Immuno-Allergology Clinic, CHU Brugmann, Université Libre de Bruxelles (ULB), Brussels, Belgium; Laboratory of Translational Research, CHU Brugmann, Université Libre de Bruxelles (ULB), Brussels, Belgium., Mahadeb B; Laboratory of Microbiology, LHUB-ULB, Brussels, Belgium., Jani JC; Department of Obstetrics and Gynaecology, CHU Brugmann, Université Libre de Bruxelles (ULB), Brussels, Belgium., Van der Linden P; Department of Anesthesiology, CHU Brugmann, Université Libre de Bruxelles (ULB), Belgium., Cannie MM; Department of Radiology, CHU Brugmann, Université Libre de Bruxelles (ULB), Brussels, Belgium., Hayef N; Department of Pharmacy (Clinical Trials), CHU Brugmann, Université Libre de Bruxelles (ULB), Brussels, Belgium., Corazza F; Laboratory of Immunology, LHUB-ULB, Brussels, Belgium; Laboratory of Translational Research, CHU Brugmann, Université Libre de Bruxelles (ULB), Brussels, Belgium., Le Pendu J; Université de Nantes, INSERM, CRCINA, Nantes, France., El Kenz H; Department of Transfusion, CHU Brugmann, Université Libre de Bruxelles (ULB), Brussels, Belgium; Laboratory of Immunology, LHUB-ULB, Brussels, Belgium.
Jazyk:	angličtina
Zdroj:	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2021 Mar; Vol. 104, pp. 242-249. Date of Electronic Publication: 2020 Dec 14.
DOI:	10.1016/j.ijid.2020.12.025
Abstrakt:	Background: Susceptibility to Covid-19 has been found to be associated with the ABO blood group, with O type individuals being at a lower risk. However, the underlying mechanism has not been elucidated. Here, we aimed to test the hypothesis that Covid-19 patients might have lower levels of ABO antibodies than non-infected individuals as they could offer some degree of protection. Methods: After showing that the viral spike protein harbors the ABO glycan epitopes when produced by cells expressing the relevant glycosyltransferases, like upper respiratory tract epithelial cells, we enrolled 290 patients with Covid-19 and 276 asymptomatic controls to compare their levels of natural ABO blood group antibodies. Results: We found significantly lower IgM anti-A + anti-B agglutination scores in blood group O patients (76.93 vs 88.29, P-value = 0.034) and lower levels of anti-B (24.93 vs 30.40, P-value = 0.028) and anti-A antibodies (28.56 vs 36.50, P-value = 0.048) in blood group A and blood group B patients, respectively, compared to controls. Conclusion: In this study, we showed that ABO antibody levels are significantly lower in Covid-19 patients compared to controls. These findings could indicate that patients with low levels of ABO antibodies are at higher risk of being infected. (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
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