Color Compensation in Anomalous Trichromats Assessed with fMRI.

Autor:	Tregillus KEM; Department of Psychology, University of Nevada, Reno, 1664 N. Virginia Street, Reno, NV 89557, USA; Department of Psychology, University of Minnesota, Twin Cities, 75 E River Road, Minneapolis, MN 55455, USA. Electronic address: kmussell@umn.edu., Isherwood ZJ; Department of Psychology, University of Nevada, Reno, 1664 N. Virginia Street, Reno, NV 89557, USA., Vanston JE; Department of Psychology, University of Nevada, Reno, 1664 N. Virginia Street, Reno, NV 89557, USA., Engel SA; Department of Psychology, University of Minnesota, Twin Cities, 75 E River Road, Minneapolis, MN 55455, USA., MacLeod DIA; Department of Psychology, University of California, San Diego, Muir Lane, La Jolla, CA 92093, USA., Kuriki I; Research Institute for Electrical Communication, Tohoku University, Sendai 2 Chome-1-1 Katahira, Aoba Ward, Sendai Miyagi 980-8577, Japan., Webster MA; Department of Psychology, University of Nevada, Reno, 1664 N. Virginia Street, Reno, NV 89557, USA.
Jazyk:	angličtina
Zdroj:	Current biology : CB [Curr Biol] 2021 Mar 08; Vol. 31 (5), pp. 936-942.e4. Date of Electronic Publication: 2020 Dec 15.
DOI:	10.1016/j.cub.2020.11.039
Abstrakt:	Anomalous trichromacy is a common form of congenital color deficiency resulting from a genetic alteration in the photopigments of the eye's light receptors. The changes reduce sensitivity to reddish and greenish hues, yet previous work suggests that these observers may experience the world to be more colorful than their altered receptor sensitivities would predict, potentially indicating an amplification of post-receptoral signals. However, past evidence suggesting such a gain adjustment rests on subjective measures of color appearance or salience. We directly tested for neural amplification by using fMRI to measure cortical responses in color-anomalous and normal control observers. Color contrast response functions were measured in two experiments with different tasks to control for attentional factors. Both experiments showed a predictable reduction in chromatic responses for anomalous trichromats in primary visual cortex. However, in later areas V2v and V3v, chromatic responses in the two groups were indistinguishable. Our results provide direct evidence for neural plasticity that compensates for the deficiency in the initial receptor color signals and suggest that the site of this compensation is in early visual cortex. Competing Interests: Declaration of Interests The authors declare no competing interests. (Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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