The direct correlation between oxidative stress and LDL-C levels in adults is maintained by the Friedewald and Martin equations, but the methylation levels in the MTHFR and ADRB3 genes differ.

Autor: Oliveira JVB; Postgraduate Program in Nutrition Sciences, Department of Nutrition, Health Sciences Centre, Federal University of Paraíba (Universidade Federal da Paraíba-UFPB), João Pessoa, Paraíba, Brazil., Lima RPA; Postgraduate Program in Nutrition Sciences, Department of Nutrition, Health Sciences Centre, Federal University of Paraíba (Universidade Federal da Paraíba-UFPB), João Pessoa, Paraíba, Brazil., Pordeus Luna RC; Postgraduate Program in Nutrition Sciences, Department of Nutrition, Health Sciences Centre, Federal University of Paraíba (Universidade Federal da Paraíba-UFPB), João Pessoa, Paraíba, Brazil., da Silva Diniz A; Postgraduate Program in Nutrition Sciences, Department of Nutrition, Health Sciences Centre, Federal University of Pernambuco (Universidade Federal de Pernambuco-UFPE), Recife, Pernambuco, Brazil., de Almeida ATC; Postgraduate Program in Applied Economics, Department of Economics, Centre for Applied Social Sciences, UFPB, João Pessoa, Paraíba, Brazil., de Oliveira NFP; Department of Molecular Biology, Centre for Exact and Natural Sciences, UFPB, João Pessoa, Paraíba, Brazil., Gonçalves MDCR; Postgraduate Program in Nutrition Sciences, Department of Nutrition, Health Sciences Centre, Federal University of Paraíba (Universidade Federal da Paraíba-UFPB), João Pessoa, Paraíba, Brazil., de Lima RT; Postgraduate Program in Nutrition Sciences, Department of Nutrition, Health Sciences Centre, Federal University of Paraíba (Universidade Federal da Paraíba-UFPB), João Pessoa, Paraíba, Brazil., de Lima Ferreira FEL; Postgraduate Program in Nutrition Sciences, Department of Nutrition, Health Sciences Centre, Federal University of Paraíba (Universidade Federal da Paraíba-UFPB), João Pessoa, Paraíba, Brazil., Diniz SCPOR; Postgraduate Program in Nutrition Sciences, Department of Nutrition, Health Sciences Centre, Federal University of Paraíba (Universidade Federal da Paraíba-UFPB), João Pessoa, Paraíba, Brazil., Silva AS; Postgraduate Program in Nutrition Sciences, Department of Nutrition, Health Sciences Centre, Federal University of Paraíba (Universidade Federal da Paraíba-UFPB), João Pessoa, Paraíba, Brazil., Andrade E Silva AH; Department of Statistics, Centre for Exact and Natural Sciences, UFPB, João Pessoa, Paraíba, Brazil., Persuhn DC; Department of Molecular Biology, Centre for Exact and Natural Sciences, UFPB, João Pessoa, Paraíba, Brazil., de Carvalho Costa MJ; Postgraduate Program in Nutrition Sciences, Department of Nutrition, Health Sciences Centre, Federal University of Paraíba (Universidade Federal da Paraíba-UFPB), João Pessoa, Paraíba, Brazil.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2020 Dec 16; Vol. 15 (12), pp. e0239989. Date of Electronic Publication: 2020 Dec 16 (Print Publication: 2020).
DOI: 10.1371/journal.pone.0239989
Abstrakt: Low-density lipoprotein (LDL-C) concentrations are a standard of care in the prevention of cardiovascular disease and are influenced by different factors. This study compared the LDL-C concentrations estimated by two different equations and determined their associations with inflammatory status, oxidative stress, anthropometric variables, food intake and DNA methylation levels in the LPL, ADRB3 and MTHFR genes. A cross-sectional population-based study was conducted with 236 adults (median age 37.5 years) of both sexes from the municipality of João Pessoa, Paraíba, Brazil. The LDL-C concentrations were estimated according to the Friedewald and Martin equations. LPL, ADRB3 and MTHFR gene methylation levels; malondialdehyde levels; total antioxidant capacity; ultra-sensitive C-reactive protein, alpha-1-acid glycoprotein, homocysteine, cobalamin, and folic acid levels; usual dietary intake; and epidemiological variables were also determined. For each unit increase in malondialdehyde concentration there was an increase in the LDL-C concentration from 6.25 to 10.29 mg/dL (p <0.000). Based on the Martin equation (≥70 mg/dL), there was a decrease in the DNA methylation levels in the ADRB3 gene and an increase in the DNA methylation levels in the MTHFR gene (p <0.05). There was a positive relation of homocysteine and cholesterol intake on LDL-C concentrations estimated according to the Friedewald equation and of waist circumference and age based on the two estimates. It is concluded the LDL-C concentrations estimated by the Friedewald and Martin equations were different, and the Friedewald equation values were significantly lower than those obtained by the Martin equation. MDA was the variable that was most positively associated with the estimated LDL-C levels in all multivariate models. Significant relationships were observed based on the two estimates and occurred for most variables. The methylation levels of the ADRB3 and MTHFR genes were different according to the Martin equation at low LDL-C concentrations (70 mg/dL).
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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