miR-424: A novel potential therapeutic target and prognostic factor in malignancies.

Autor: Dastmalchi N; Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran., Baradaran B; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Banan Khojasteh SM; Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran., Hosseinpourfeizi M; Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran., Safaralizadeh R; Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Jazyk: angličtina
Zdroj: Cell biology international [Cell Biol Int] 2021 Apr; Vol. 45 (4), pp. 720-730. Date of Electronic Publication: 2020 Dec 25.
DOI: 10.1002/cbin.11530
Abstrakt: microRNAs are endogenous, noncoding RNAs. Showing both tumor-suppressive and oncogenic characteristics, miRNAs can regulate important processes in malignancies. This review aimed at highlighting the recent studies on the contribution of miR-424 to the modulation of carcinogenesis and exploring its probable clinical effectiveness in the diagnosis and therapy of malignancies. The data were extracted from all papers published from 2013 until 2020. Mature miR-424 leads to the degradation of its target transcripts or the suppression of translation via binding to the molecular targets. miR-424 is involved in modulating p53, PI3K/Akt, Wnt, and other molecular pathways, thereby regulating cellular growth, apoptosis, differentiation, chemoresistance, and cancer immunity. miR-424 was introduced as a tumor-suppressive miR in numerous types of cancers while as an oncogene in several cancers. Regarding the cancer dependent role of miR-424, it may be a prognostic and diagnostic biomarker and a potential candidate for the treatment of cancers.
(© 2020 International Federation for Cell Biology.)
Databáze: MEDLINE
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