Intense Hypermetabolic Tumefactive Demyelination on 18F-FDG PET and MRI Related to Multiple Sclerosis Relapse After Fingolimod Suspension.
| Autor: | Pimentel GA; From the Neurology., Coutinho AM; Nuclear Medicine., de Souza Godoy LF; Center for Diagnostic Imaging, Radiology Service., de Lima LGCA; Pathology, Hospital Sirio Libanes, São Paulo, Brazil., de Andrade DC; From the Neurology. |
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| Jazyk: | angličtina |
| Zdroj: | Clinical nuclear medicine [Clin Nucl Med] 2021 Apr 01; Vol. 46 (4), pp. e198-e199. |
| DOI: | 10.1097/RLU.0000000000003419 |
| Abstrakt: | Abstract: A 57-year-old woman with a history of multiple sclerosis presented with a 5-day history of progressive headache and confusion, followed by left hemiparesis. The patient had stopped her previous fingolimod usage during the last 8 weeks. Brain MRI and 18F-FDG PET showed a subcortical tumefactive lesion with an intense peripheric rim of hypermetabolism and central hypometabolism, with central hyperintensity, thin isointense rim, and peripheral finger-like "tentacles" of edema with an irregular and thick border enhancement on postcontrast T2-weighted MRI. Brain biopsy showed features suggestive of relapsing MS. The patient improved after methylprednisone and plasma exchange. Competing Interests: Conflicts of interest and sources of funding: None declared. (Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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