Genome sequences of antibiotic-resistant Streptococcus suis strains isolated from human patients and diseased and asymptomatic pigs in Thailand.

Autor: Yongkiettrakul S; National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathum Thani, Thailand. Electronic address: suganya.yon@biotec.or.th., Wongsurawat T; Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Division of Bioinformatics and Data Management for Research, Department of Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand., Jenjaroenpun P; Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Division of Bioinformatics and Data Management for Research, Department of Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand., Acheampong DA; Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Joint Graduate Program in Bioinformatics, University of Arkansas at Little Rock and University of Arkansas for Medical Sciences, Little Rock, AR, USA., Srimanote P; Graduate Program in Biomedical Sciences, Faculty of Allied Health Sciences, Thammasat University, Pathum Thani, Thailand., Maneerat K; College of Alternative Medicine, Chandrakasem Rajabhat University, Bangkok, Thailand., Visessanguan W; National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathum Thani, Thailand., Nookaew I; Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address: INookaew@uams.edu.
Jazyk: angličtina
Zdroj: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2021 Jan; Vol. 87, pp. 104674. Date of Electronic Publication: 2020 Dec 13.
DOI: 10.1016/j.meegid.2020.104674
Abstrakt: Streptococcus suis, a zoonotic bacterial pathogen, has negative economic impacts on both intensive swine production and human health worldwide. Whole-genome sequencing and comparative genomic analysis have been widely used for comprehensive classification and investigation of the genetic basis of several S. suis strains obtained from distinct hosts in different geographic areas, revealing great genetic diversity of this zoonotic pathogen. In this study, whole-genome sequences of antibiotic-resistant S. suis strains isolated from human patients (2 strains), diseased pigs (4 strains), and asymptomatic pigs (3 strains) in Thailand were compared with known genomes of 1186 S. suis strains. Single-nucleotide polymorphism-based phylogenetic analysis indicated that the Thai-isolated S. suis strains have close genetic relatedness to S. suis strains isolated from Canada, China, Denmark, Netherlands, United Kingdom, and United States of America. The genome analysis revealed genes conferring antibiotic resistance (aad(6), ant(6)-Ia, ermB, tet(O), patB, and sat4) and gene clusters (aph(3')-IIIa and aac(6')-Ie-aph(2″)-Ia) associated with aminoglycoside, macrolide, and fluoroquinolone resistance in S. suis in Thailand. This work provides additional resources for future genomic epidemiology investigation of S. suis.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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