The connectome of the adult Drosophila mushroom body provides insights into function.

Autor:	Li F; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Lindsey JW; Department of Neuroscience, Columbia University, Zuckerman Institute, New York, United States., Marin EC; Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom., Otto N; Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom.; Centre for Neural Circuits & Behaviour, University of Oxford, Oxford, United Kingdom., Dreher M; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Dempsey G; Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom., Stark I; Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom., Bates AS; Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom., Pleijzier MW; Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom., Schlegel P; Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom.; Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom., Nern A; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Takemura SY; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Eckstein N; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Yang T; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Francis A; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Braun A; Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom., Parekh R; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Costa M; Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom., Scheffer LK; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Aso Y; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Jefferis GS; Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom.; Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom., Abbott LF; Department of Neuroscience, Columbia University, Zuckerman Institute, New York, United States., Litwin-Kumar A; Department of Neuroscience, Columbia University, Zuckerman Institute, New York, United States., Waddell S; Centre for Neural Circuits & Behaviour, University of Oxford, Oxford, United Kingdom., Rubin GM; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2020 Dec 14; Vol. 9. Date of Electronic Publication: 2020 Dec 14.
DOI:	10.7554/eLife.62576
Abstrakt:	Making inferences about the computations performed by neuronal circuits from synapse-level connectivity maps is an emerging opportunity in neuroscience. The mushroom body (MB) is well positioned for developing and testing such an approach due to its conserved neuronal architecture, recently completed dense connectome, and extensive prior experimental studies of its roles in learning, memory, and activity regulation. Here, we identify new components of the MB circuit in Drosophila , including extensive visual input and MB output neurons (MBONs) with direct connections to descending neurons. We find unexpected structure in sensory inputs, in the transfer of information about different sensory modalities to MBONs, and in the modulation of that transfer by dopaminergic neurons (DANs). We provide insights into the circuitry used to integrate MB outputs, connectivity between the MB and the central complex and inputs to DANs, including feedback from MBONs. Our results provide a foundation for further theoretical and experimental work. Competing Interests: FL, JL, EM, NO, MD, GD, IS, AB, MP, PS, AN, ST, NE, TY, AF, AB, RP, MC, LS, YA, GJ, LA, AL, SW, GR No competing interests declared (© 2020, Li et al.)
Databáze:	MEDLINE
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