Assessing the relationship between institutional cancer and diabetes mortality rates using National Death Index data.

Autor: Karlin NJ; Division of Hematology & Medical Oncology, Mayo Clinic Hospital, Phoenix, AZ 85054, USA.; Mayo Clinic Cancer Center, Scottsdale, AZ 85259, USA., Buras MR; Biostatistics, Mayo Clinic, Scottsdale, AZ 85259, USA., Kosiorek HE; Biostatistics, Mayo Clinic, Scottsdale, AZ 85259, USA., Coppola KE; Mayo Clinic Cancer Center, Scottsdale, AZ 85259, USA., Verona PM; Department of Information Technology, Mayo Clinic Hospital, Phoenix, AZ 85054, USA., Cook CB; Division of Endocrinology, Mayo Clinic, Scottsdale, AZ 85259, USA.
Jazyk: angličtina
Zdroj: Future science OA [Future Sci OA] 2020 Oct 20; Vol. 6 (10), pp. FSO633. Date of Electronic Publication: 2020 Oct 20.
DOI: 10.2144/fsoa-2020-0055
Abstrakt: Aim: To evaluate overall survival (OS), glycemic control in cancer patients with and without diabetes mellitus (DM).
Patients & Methods: Patients (2010-2015) with newly diagnosed prostate, breast, lung, colorectal and pancreatic cancers were identified in institutional cancer registry. Data linked to National Death Index for vital status. 5-year OS estimated; glucose and hemoglobin A 1c assessed during year postdiagnosis.
Results: We identified 1404 patients (non-DM, n = 936; DM, n = 468). DM cohort had 168 deaths (36%); non-DM, 267 (29%). 5-year OS estimated at 58% (95% CI: 53-64%) for DM and 67% (95% CI: 64-71%) for controls; for matched pairs, hazard ratio: 1.35 (95% CI: 1.02-1.79). Cancer did not harm glycemic control.
Conclusion: OS among cancer patients with DM was lower than without DM.
Competing Interests: Financial & competing interests disclosure The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.
(© 2020 Mayo Foundation for Medical Education and Research.)
Databáze: MEDLINE
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