Association of hypoalbuminemia and reversal of albumin-to-globulin ratio with morbidity outcome among hospitalized Lassa fever infected patients at a dedicated treatment center in Ondo state, south-western Nigeria.

Autor:	Owhin SO; Department of Internal Medicine and Hemato-oncology Unit, Federal Medical Center Owo, Ondo State, Nigeria., Abejegah C; Department of Community Medicine, Federal Medical Center Owo, Ondo State, Nigeria., Fasipe OJ; Department of Clinical Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, University of Medical Sciences, Ondo City, Ondo State, Nigeria., Oke C; Department of Community Medicine, Federal Medical Center Owo, Ondo State, Nigeria., Abidoye A; Department of Community Medicine, Federal Medical Center Owo, Ondo State, Nigeria., Osagbaekhoe A; Department of Community Medicine, Federal Medical Center Owo, Ondo State, Nigeria., Awe A; Department of Community Medicine, Federal Medical Center Owo, Ondo State, Nigeria., Etafo I; Department of Community Medicine, Federal Medical Center Owo, Ondo State, Nigeria., Iredia E; Department of Community Medicine, Federal Medical Center Owo, Ondo State, Nigeria., Ayodeji O; Department of Community Medicine, Federal Medical Center Owo, Ondo State, Nigeria., Olatunde L; Department of Internal Medicine and Hemato-oncology Unit, Federal Medical Center Owo, Ondo State, Nigeria., Ojo O; Department of Internal Medicine and Hemato-oncology Unit, Federal Medical Center Owo, Ondo State, Nigeria., Alabi J; Department of Nursing, Federal Medical Center Owo, Ondo State, Nigeria., Akhideno PE; Department of Internal Medicine, Irrua Specialist Teaching Hospital Irrua, Edo State, Nigeria., Ejiyere H; Department of Internal Medicine, Irrua Specialist Teaching Hospital Irrua, Edo State, Nigeria., Stephen Adeke A; Department of Community Medicine, Alex Ekwueme Federal University Teaching Hospital Abakaliki, Ebonyi State, Nigeria., Azegbeobor J; Department of Psychiatry, Federal Medical Center Owo, Ondo State, Nigeria., Ahmed L; Office of the Chief Medical Director, Federal Medical Center, Owo, Ondo State, Nigeria.
Jazyk:	angličtina
Zdroj:	Future science OA [Future Sci OA] 2020 Aug 13; Vol. 6 (10), pp. FSO620. Date of Electronic Publication: 2020 Aug 13.
DOI:	10.2144/fsoa-2020-0075
Abstrakt:	Background: As of this present moment, there is paucity of data on report concerning the association between hypoalbuminaemia or reversal of albumin-to-globulin ratio and morbidity outcome in Lassa fever (LF) infection as a crucial determinant prognostic-predictor factor for treatment-survival outcome. Aim: This study was designed to determine the association between hypoalbuminaemia, reversal of albumin-to-globulin ratio and morbidity outcome among confirmed LF infected patients. Methodology: This was a descriptive retrospective study involving the assessment of records of confirmed LF infected patients that were managed at the center from November 2018 to October 2019. Results: Out of 83 recruited participants with complete records, 66 (79.5%) had hypoalbuminaemia, 74 (89.2%) had reversal of albumin-to-globulin ratio. A higher mean value of total white blood cell (WBC) count was observed among patients with hypoalbuminaemia (p < 0.0001) and reversal of albumin-to-globulin ratio (p < 0.0001) when compared to patients with normal values, respectively. Also, this study showed statistically significant associations between serum albumin level versus total WBC count (p < 0.0001), acute kidney injury (AKI; p = 0.009), bleeding diathesis (p < 0.0001), and occurrence of pregnancy miscarriage (p < 0.0001). Conclusion: There is a baseline hypoalbuminaemia and reversal of albumin-to-globulin ratio among confirmed LF infected patients. Based on these findings, the serum level of albumin and albumin-to-globulin ratio at presentation may serve as simple early biomarkers to identify patients at high risk for a complicated clinical course of disease. This study also reveals that those hospitalized LF infected patients with hypoalbuminemia and/or reversal of albumin-to-globulin ratio tend to have leucocytosis and experience prolonged duration of illness. Competing Interests: Financial & competing interests disclosure The authors funded this research with personal funds and are not in any way obliged to any individual or organization in regard to part or the whole of this work. The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript. (© 2020 Olumuyiwa John Fasipe.)
Databáze:	MEDLINE
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