| Autor: |
Ratchford SM; Department of Health & Exercise Science, Appalachian State University, Boone, North Carolina., Stickford JL; Department of Health & Exercise Science, Appalachian State University, Boone, North Carolina., Province VM; Department of Health & Exercise Science, Appalachian State University, Boone, North Carolina., Stute N; Department of Health & Exercise Science, Appalachian State University, Boone, North Carolina., Augenreich MA; Department of Health & Exercise Science, Appalachian State University, Boone, North Carolina., Koontz LK; Department of Health & Exercise Science, Appalachian State University, Boone, North Carolina., Bobo LK; Department of Health & Exercise Science, Appalachian State University, Boone, North Carolina., Stickford ASL; Department of Health & Exercise Science, Appalachian State University, Boone, North Carolina. |
| Jazyk: |
angličtina |
| Zdroj: |
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2021 Jan 01; Vol. 320 (1), pp. H404-H410. Date of Electronic Publication: 2020 Dec 11. |
| DOI: |
10.1152/ajpheart.00897.2020 |
| Abstrakt: |
While SARS-CoV-2 primarily affects the lungs, the virus may be inflicting detriments to the cardiovascular system, both directly through angiotensin-converting enzyme 2 receptor and initiating systemic inflammation. Persistent systemic inflammation may be provoking vascular dysfunction, an early indication of cardiovascular disease risk. To establish the potential effects of SARS-CoV-2 on the systemic vasculature in the arms and legs, we performed a cross-sectional analysis of young healthy adults (control: 5 M/15 F, 23.0 ± 1.3 y, 167 ± 9 cm, 63.0 ± 7.4 kg) and young adults who, 3-4 wk prior to testing, had tested positive for SARS-CoV-2 (SARS-CoV-2: 4 M/7 F, 20.2 ± 1.1 y, 172 ± 12 cm, 69.5 ± 12.4 kg) (means ± SD). Using Doppler ultrasound, brachial artery flow-mediated dilation (FMD) in the arm and single passive limb movement (sPLM) in the leg were assessed as markers of vascular function. Carotid-femoral pulse wave velocity (PWVcf) was asvsessed as a marker of arterial stiffness. FMD was lower in the SARS-CoV-2 group (2.71 ± 1.21%) compared with the control group (8.81 ± 2.96%) ( P < 0.01) and when made relative to the shear stimulus (SARS-CoV-2: 0.04 ± 0.02 AU, control: 0.13 ± 0.06 AU, P < 0.01). The femoral artery blood flow response, as evidenced by the area under the curve, from the sPLM was lower in the SARS-CoV-2 group (-3 ± 91 mL) compared with the control group (118 ± 114 mL) ( P < 0.01). PWVcf was higher in the SARS-CoV-2 group (5.83 ± 0.62 m/s) compared with the control group (5.17 ± 0.66 m/s) ( P < 0.01). Significantly lower systemic vascular function and higher arterial stiffness are evident weeks after testing positive for SARS-CoV-2 among young adults compared with controls. NEW & NOTEWORTHY This study was the first to investigate the vascular implications of contracting SARS-CoV-2 among young, otherwise healthy adults. Using a cross-sectional design, this study assessed vascular function 3-4 wk after young adults tested positive for SARS-CoV-2. The main findings from this study were a strikingly lower vascular function and a higher arterial stiffness compared with healthy controls. Together, these results suggest rampant vascular effects seen weeks after contracting SARS-CoV-2 in young adults. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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