| Autor: |
Milzarek TM; Chair of Technical Biochemistry, Technical University of Dresden, Bergstraße 66, 01069 Dresden, Germany., Gulder TAM; Chair of Technical Biochemistry, Technical University of Dresden, Bergstraße 66, 01069 Dresden, Germany. |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2021 Jan 01; Vol. 23 (1), pp. 102-106. Date of Electronic Publication: 2020 Dec 11. |
| DOI: |
10.1021/acs.orglett.0c03784 |
| Abstrakt: |
The first total synthesis of all members of the cyanobacterial natural product class of the ambigols is described. Key steps of the synthetic strategy are the formation of sterically demanding mono- and bis-iodonium salts to install the required biaryl ether structural elements and Suzuki cross-coupling giving straightforward access to the biaryl bonds. The synthetic methods are also utilized to construct unnatural or hypothetical ambigols that are still awaiting discovery from Nature. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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