[Treatment of severe post-resection liver failure. Analysis of the specialized center].

Autor:	Alikhanov RB; Loginov Moscow clinical research center of the Moscow Department of health, Moscow, Russia., Efanov MG; Loginov Moscow clinical research center of the Moscow Department of health, Moscow, Russia., Subbotin VV; Loginov Moscow clinical research center of the Moscow Department of health, Moscow, Russia., Novikova EV; Loginov Moscow clinical research center of the Moscow Department of health, Moscow, Russia., Shchadrina KV; Loginov Moscow clinical research center of the Moscow Department of health, Moscow, Russia., Buldakov MY; Loginov Moscow clinical research center of the Moscow Department of health, Moscow, Russia.
Jazyk:	ruština
Zdroj:	Khirurgiia [Khirurgiia (Mosk)] 2020 (12), pp. 88-92.
DOI:	10.17116/hirurgia202012188
Abstrakt:	Posthepatectomy liver failure is one of the most serious complications of large liver resections. Objective: The analyzes the management and results of treatment of patients with severe posthepatectomy liver failure (Grade C ISGLS) in a specialized hepatosurgical department. Material and Methods: In the period from January to December 2019, 175 liver resections were performed in the Department of liver and pancreatic surgery at the A.S. Loginov Moscow Clinical Scientific Center. Major-volume liver resections (hemihepatectomies and resections of more than three liver segments) were performed in 80 (45%) patients. In 125 (71%) cases liver resctions were performed for malignant liver and bile duct diseases. Laparoscopic liver resections were performed in 77 (44%) patients. Results: Postresection liver failure developed in 18 (10.2%) patients. Severe (class C according to ISGLS) developed in 6 (3.4%) patients. In the postoperative period (90-day mortality), 4 patients (2.3%) died, while in two patients, mortality was not associated with liver failure. Hyperbilirubinemia was observed for more than 5 days in 2 (33.3%), coagulopathy in 4 (66.6%), ascites in 5 (83.3%), encephalopathy in 5 (83.3%), hypoglycemia in 3 (50%), and uncontrolled sepsis in 2 (33.3%) patients, respectively. Correction of surgical complications was required in 100% of cases, which consisted in drainage of abscesses and abdominal bylomas, and the the bilio-digestive anastomosis fistulas. Inotropic support was required in all 6 (100%) patients, invasive ventilation in 4(66.6%), and extracorporeal detoxification in 5 (83.3%). Conclusions: Posthepatectomy liver failure is a complex problem even in a specialized center. A comprehensive approach to treatment allows to achieve noticeable results and reduce mortality.
Databáze:	MEDLINE
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