Predictors of maternal-origin microchimerism in young women in the Philippines.

Autor: Pan TD; Department of Anthropology, University of Washington, Seattle, Washington, USA.; Center for Studies in Demography and Ecology, University of Washington, Seattle, Washington, USA., Kanaan SB; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Lee NR; USC-Office of Population Studies Foundation, Inc., Cebu City, Philippines.; Department of Anthropology, Sociology & History, University of San Carlos, Cebu City, Philippines., Avila JL; USC-Office of Population Studies Foundation, Inc., Cebu City, Philippines.; Department of Architecture, School of Architecture, Fine Arts and Design, University of San Carlos, Cebu City, Philippines., Nelson JL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.; Department of Medicine, University of Washington, Seattle, Washington, USA., Eisenberg DTA; Department of Anthropology, University of Washington, Seattle, Washington, USA.; Center for Studies in Demography and Ecology, University of Washington, Seattle, Washington, USA.; Department of Biology, University of Washington, Seattle, Washington, USA.
Jazyk: angličtina
Zdroj: American journal of physical anthropology [Am J Phys Anthropol] 2021 Feb; Vol. 174 (2), pp. 213-223. Date of Electronic Publication: 2020 Dec 09.
DOI: 10.1002/ajpa.24191
Abstrakt: Objectives: Microchimerism is the presence of a small quantity of cells or DNA from a genetically distinct individual. This phenomenon occurs with bidirectional maternal-fetal exchange during pregnancy. Microchimerism can persist for decades after delivery and have long-term health implications. However, little is known about why microchimerism is detectable at varying levels in different individuals. We examine the variability and the following potential determinants of maternal-origin microchimerism (MMc) in young women in the Philippines: gestational duration (in utero exposure to MMc), history of being breastfed (postpartum exposure to MMc), maternal telomere length (maternal cells' ability to replicate and persist), and participant's pregnancies in young adulthood (effect of adding fetal-origin microchimerism to preexisting MMc).
Materials and Methods: Data are from the Cebu Longitudinal Health and Nutrition Survey, a population-based study of infant feeding practices and long-term health outcomes. We quantified MMc using quantitative PCR (qPCR) in 89 female participants, ages 20-22, and analyzed these data using negative binomial regression.
Results: In a multivariate model including all predictors, being breastfed substantially predicted decreased MMc (detection rate ratio = 0.15, p = 0.007), and there was a trend of decreasing MMc in participants who had experienced more pregnancies (detection rate ratio = 0.55, p = 0.057).
Discussion: These results might be explained by breastfeeding having lasting impact on immune regulatory networks, thus reducing MMc persistence. MMc may also decrease in response to the introduction of fetal-origin microchimerism with pregnancies experienced in adulthood.
(© 2020 Wiley Periodicals LLC.)
Databáze: MEDLINE
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