Layer 3 Pyramidal Cells in the Medial Entorhinal Cortex Orchestrate Up-Down States and Entrain the Deep Layers Differentially.

Autor:	Beed P; Charité-Universitätsmedizin Berlin, Neuroscience Research Center, 10117 Berlin, Germany; Berlin Institute of Health, 10178 Berlin, Germany. Electronic address: prateep.beed@charite.de., de Filippo R; Charité-Universitätsmedizin Berlin, Neuroscience Research Center, 10117 Berlin, Germany., Holman C; Charité-Universitätsmedizin Berlin, Neuroscience Research Center, 10117 Berlin, Germany., Johenning FW; Charité-Universitätsmedizin Berlin, Neuroscience Research Center, 10117 Berlin, Germany; Berlin Institute of Health, 10178 Berlin, Germany; Cluster of Excellence NeuroCure, 10117 Berlin, Germany., Leibold C; Department Biologie II, Ludwig-Maximilians-Universität München, 82152 Munich, Germany; Bernstein Center for Computational Neuroscience Munich, 82152 Munich, Germany., Caputi A; Department of Clinical Neurobiology, Medical Faculty of Heidelberg University and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany., Monyer H; Department of Clinical Neurobiology, Medical Faculty of Heidelberg University and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany., Schmitz D; Charité-Universitätsmedizin Berlin, Neuroscience Research Center, 10117 Berlin, Germany; Berlin Institute of Health, 10178 Berlin, Germany; German Center for Neurodegenerative Diseases (DZNE) Berlin, 10117 Berlin, Germany; Cluster of Excellence NeuroCure, 10117 Berlin, Germany; Einstein Center for Neurosciences Berlin, 10117 Berlin, Germany. Electronic address: dietmar.schmitz@charite.de.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2020 Dec 08; Vol. 33 (10), pp. 108470.
DOI:	10.1016/j.celrep.2020.108470
Abstrakt:	Up-down states (UDS) are synchronous cortical events of neuronal activity during non-REM sleep. The medial entorhinal cortex (MEC) exhibits robust UDS during natural sleep and under anesthesia. However, little is known about the generation and propagation of UDS-related activity in the MEC. Here, we dissect the circuitry underlying UDS generation and propagation across layers in the MEC using both in vivo and in vitro approaches. We provide evidence that layer 3 (L3) MEC is crucial in the generation and maintenance of UDS in the MEC. Furthermore, we find that the two sublayers of the L5 MEC participate differentially during UDS. Our findings show that L5b, which receives hippocampal output, is strongly innervated by UDS activity originating in L3 MEC. Our data suggest that L5b acts as a coincidence detector during information transfer between the hippocampus and the cortex and thereby plays an important role in memory encoding and consolidation. Competing Interests: Declaration of Interests The authors declare no competing interests. (Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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