Castanea sativa Mill. bark extract cardiovascular effects in a rat model of high-fat diet.

Autor: Micucci M; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Bologna, Italy., Budriesi R; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Bologna, Italy., Aldini R; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Bologna, Italy., Fato R; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Bologna, Italy., Bergamini C; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Bologna, Italy., Vivarelli F; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Bologna, Italy., Canistro D; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Bologna, Italy., Bolchi C; Department of Pharmaceutical Sciences 'Pietro Pratesi', Università degli Studi di Milano, Milan, Italy., Chiarini A; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Bologna, Italy., Rizzardi N; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Bologna, Italy., Pallavicini M; Department of Pharmaceutical Sciences 'Pietro Pratesi', Università degli Studi di Milano, Milan, Italy., Frosini M; Department of Life Sciences, University of Siena, Siena, Italy., Angeletti A; Department of Specialistic, Experimental and Diagnostic Medicine, Alma Mater Studiorum-University of Bologna. S. Orsola Hospital, Bologna, Italy.
Jazyk: angličtina
Zdroj: Phytotherapy research : PTR [Phytother Res] 2021 Apr; Vol. 35 (4), pp. 2145-2156. Date of Electronic Publication: 2020 Dec 08.
DOI: 10.1002/ptr.6967
Abstrakt: Ellagitannins may have a beneficial impact in cardiovascular diseases. The aim of the study was to evaluate the effect of high-fat diet (HFD) and the efficacy of Castanea sativa Mill. bark extract (ENC) on cardiac and vascular parameters. Rats were fed with regular diet, (RD, n = 15), HFD (n = 15), RD + ENC (20 mg/kg/day by gavage, n = 15), and HFD + ENC (same dose, n = 15) and the effects on body weight, biochemical serum parameters, and inflammatory cytokines determined. Cardiac functional parameters and aorta contractility were also assessed on isolated atria and aorta. Results showed that ENC reduced weight gain and serum lipids induced by HFD. In in vitro assays, HFD decreased the contraction force of left atrium, increased right atrium chronotropy, and decreased aorta K + -induced contraction; ENC induced transient positive inotropic and negative chronotropic effects on isolated atria from RD and HFD rats and a spasmolytic effect on aorta. In ex vivo experiments, ENC reverted inotropic and chronotropic changes induced by HFD and enhanced Nifedipine effect more on aorta than on heart. In conclusion, ENC restores metabolic dysfunction and cardiac cholinergic muscarinic receptor function, and exerts spasmolytic effect on aorta in HFD rats, highlighting its potential as nutraceutical tool in obesity.
(© 2020 John Wiley & Sons, Ltd.)
Databáze: MEDLINE
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