Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature.

Autor:	Dhariwala MO; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA., Karthikeyan D; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA., Vasquez KS; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA., Farhat S; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA., Weckel A; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA., Taravati K; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA., Leitner EG; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA., Clancy S; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA., Pauli M; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA., Piper ML; Division of Plastic and Reconstructive Surgery, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA., Cohen JN; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA., Ashouri JF; Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Division of Rheumatology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA., Lowe MM; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA., Rosenblum MD; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA., Scharschmidt TC; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Jazyk:	angličtina
Zdroj:	Cell reports. Medicine [Cell Rep Med] 2020 Nov 03; Vol. 1 (8), pp. 100132. Date of Electronic Publication: 2020 Nov 03 (Print Publication: 2020).
DOI:	10.1016/j.xcrm.2020.100132
Abstrakt:	Lymphocytes in barrier tissues play critical roles in host defense and homeostasis. These cells take up residence in tissues during defined developmental windows, when they may demonstrate distinct phenotypes and functions. Here, we utilized mass and flow cytometry to elucidate early features of human skin immunity. Although most conventional αβ T (Tconv) cells in fetal skin have a naive, proliferative phenotype, a subset of CD4 + Tconv and CD8 + cells demonstrate memory-like features and a propensity for interferon (IFN)γ production. Skin regulatory T cells dynamically accumulate over the second trimester in temporal and regional association with hair follicle development. These fetal skin regulatory T cells (Tregs) demonstrate an effector memory phenotype while differing from their adult counterparts in expression of key effector molecules. Thus, we identify features of prenatal skin lymphocytes that may have key implications for understanding antigen and allergen encounters in utero and in infancy. Competing Interests: M.D.R. is a founder and consultant for TRex Bio and Sitryx Bio and receives research funding from Abbvie, TRex, and LEO Pharma. K.T. is currently an employee of Amgen. E.G.L. is currently an employee of SentiBio. All other authors declare no competing interests. (© 2020 The Author(s).)
Databáze:	MEDLINE
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