Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancy.
| Autor: | Mahpour A; Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA.; Harvard Medical School, Boston, MA 02115, USA., Mullen AC; Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA.; Harvard Medical School, Boston, MA 02115, USA.; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. |
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| Jazyk: | angličtina |
| Zdroj: | JHEP reports : innovation in hepatology [JHEP Rep] 2020 Sep 03; Vol. 3 (1), pp. 100177. Date of Electronic Publication: 2020 Sep 03 (Print Publication: 2021). |
| DOI: | 10.1016/j.jhepr.2020.100177 |
| Abstrakt: | Long non-coding RNAs (lncRNAs) are important biological mediators that regulate numerous cellular processes. New experimental evidence suggests that lncRNAs play essential roles in liver development, normal liver physiology, fibrosis, and malignancy, including hepatocellular carcinoma and cholangiocarcinoma. In this review, we summarise our current understanding of the function of lncRNAs in the liver in both health and disease, as well as discuss approaches that could be used to target these non-coding transcripts for therapeutic purposes. Competing Interests: The authors declare no conflicts of interest that pertain to this work. Please refer to the accompanying ICMJE disclosure forms for further details. (© 2020 The Authors.) |
| Databáze: | MEDLINE |
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