| Autor: |
Símaro GV; Núcleo de Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, Brazil.; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil., Lemos M; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil., Silva JJMD; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil., Cunha WR; Núcleo de Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, Brazil., Carneiro LJ; Núcleo de Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, Brazil., Ambrósio SR; Núcleo de Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, Brazil., Cunha NL; Núcleo de Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, Brazil., de Andrade SF; CBIOS - Research Center for Biosciences and Health Technologies, Universidade Lusófona, Lisboa, Portugal., Arruda C; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil., Banderó-Filho VC; CBIOS - Research Center for Biosciences and Health Technologies, Universidade Lusófona, Lisboa, Portugal., Sasse A; NatPro Centre. School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, University of Dublin, Dublin, Ireland., Sheridan H; NatPro Centre. School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, University of Dublin, Dublin, Ireland., Bastos JK; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil., Silva MLAE; Núcleo de Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, Brazil. |
| Abstrakt: |
Copaifera pubiflora Benth oleoresin (CPO) is used as an anti-inflammatory, wound healing, and antimicrobial. This paper reports the cytotoxic, anti-inflammatory, and antinociceptive activities of CPO. CPO (10 mg/kg) did not affect locomotor capacity in the open-field and rotarod tests and was not cytotoxic to CHO-k1, THP-1, and L929 cell lines. It was active in the formalin test at 3 mg/kg by 86 ± 3% and 96 ± 3%, respectively, for the first and second phases. At 10 mg/kg, CPO inhibited 90 ± 7%, the pain in the mechanical hyperalgesia test. In the tail-flick test, CPO at 3 mg/kg affected the tail-flick latencies in mice by 77 ± 20%, which in combination with naloxone was only partially reduced. At 3 mg/kg CPO inhibited 80 ± 12% the carrageenan-induced paw edema, and at 3 mg/kg it reduced by 91 ± 5% the nociception on acetic acid-induced abdominal writhing. Therefore, CPO possesses anti-inflammatory and antinociceptive activities. |
