| Autor: |
Bhattacharyya A; Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, India. arc@iisc.ac.in., Jameei A, Saha R, Garai A, Karande AA, Chakravarty AR |
| Jazyk: |
angličtina |
| Zdroj: |
Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2021 Jan 07; Vol. 50 (1), pp. 103-115. Date of Electronic Publication: 2020 Dec 08. |
| DOI: |
10.1039/d0dt03342a |
| Abstrakt: |
Dipicolylamine (dpa) based cis-dichlorido zinc(ii) complexes [Zn(L 1-3 )Cl 2 ] (1-3), where L 2 and L 3 are non-iodo and di-iodo BODIPY-appended dpa in 2 and 3, and L 1 is dpa in control complex 1, were prepared and characterized and their photocytotoxicity was studied. Complexes 2 and 3 were developed as potential substitutes for zinc(ii)-porphyrins/phthalocyanines that are photodynamic therapeutic agents with moderate activity owing to their inherent hydrophobicity and aggregation-induced deactivation mechanism. In our approach, we strategically designed hybrid inorganic-organic zinc-BODIPY conjugates as theranostic photosensitizers. The structurally characterized diamagnetic Zn(ii) cis-dichlorido complexes mimic cisplatin and serve as new-generation photosensitizers with enhanced aqueous solubility and mito-DNA targeting propensity while imparting significant physiological stability to the heavy atom tethered BODIPY ligand, L 3 . The BODIPY complexes showed a visible band near 500 nm (ε∼ 34 000-44 000 dm 3 mol -1 cm -1 ) and an emission band at 507 nm for 2 in 1% DMSO-Dulbecco's phosphate buffered saline. The labile chlorido ligands (Λ M ∼ 200 S m 2 mol -1 in 9 : 1 H 2 O-DMSO) generated positively charged complexes inside the cellular medium enabling them to cross the mitochondrial membrane for this organelle-selective localization and singlet oxygen-mediated apoptotic photocytotoxicity at nanomolar concentrations for 3 in HeLa and MCF-7 cells in light (400-700 nm), while being less active in the dark. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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