Bacterial Metabolites of Human Gut Microbiota Correlating with Depression.

Autor: Averina OV; Vavilov Institute of General Genetics, Russion Academy of Sciences, 119991 Moscow, Russia., Zorkina YA; Vavilov Institute of General Genetics, Russion Academy of Sciences, 119991 Moscow, Russia.; Department Basic and Applied Neurobiology, V.P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, 119034 Moscow, Russia.; Mental-Health Clinic No. 1 Named after N.A. Alexeev of Moscow Healthcare Department, 117152 Moscow, Russia., Yunes RA; Vavilov Institute of General Genetics, Russion Academy of Sciences, 119991 Moscow, Russia., Kovtun AS; Vavilov Institute of General Genetics, Russion Academy of Sciences, 119991 Moscow, Russia., Ushakova VM; Department Basic and Applied Neurobiology, V.P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, 119034 Moscow, Russia.; Department of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Morozova AY; Department Basic and Applied Neurobiology, V.P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, 119034 Moscow, Russia.; Mental-Health Clinic No. 1 Named after N.A. Alexeev of Moscow Healthcare Department, 117152 Moscow, Russia., Kostyuk GP; Mental-Health Clinic No. 1 Named after N.A. Alexeev of Moscow Healthcare Department, 117152 Moscow, Russia., Danilenko VN; Vavilov Institute of General Genetics, Russion Academy of Sciences, 119991 Moscow, Russia.; Faculty of Ecology, International Institute for Strategic Development of Sectoral Economics, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia., Chekhonin VP; Department Basic and Applied Neurobiology, V.P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, 119034 Moscow, Russia.; Department of Medical Nanobiotechnology, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2020 Dec 03; Vol. 21 (23). Date of Electronic Publication: 2020 Dec 03.
DOI: 10.3390/ijms21239234
Abstrakt: Depression is a global threat to mental health that affects around 264 million people worldwide. Despite the considerable evolution in our understanding of the pathophysiology of depression, no reliable biomarkers that have contributed to objective diagnoses and clinical therapy currently exist. The discovery of the microbiota-gut-brain axis induced scientists to study the role of gut microbiota (GM) in the pathogenesis of depression. Over the last decade, many of studies were conducted in this field. The productions of metabolites and compounds with neuroactive and immunomodulatory properties among mechanisms such as the mediating effects of the GM on the brain, have been identified. This comprehensive review was focused on low molecular weight compounds implicated in depression as potential products of the GM. The other possible mechanisms of GM involvement in depression were presented, as well as changes in the composition of the microbiota of patients with depression. In conclusion, the therapeutic potential of functional foods and psychobiotics in relieving depression were considered. The described biomarkers associated with GM could potentially enhance the diagnostic criteria for depressive disorders in clinical practice and represent a potential future diagnostic tool based on metagenomic technologies for assessing the development of depressive disorders.
Databáze: MEDLINE
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