Smoking Genes: A Case-Control Study of Dopamine Transporter Gene ( SLC6A3 ) and Dopamine Receptor Genes ( DRD1 , DRD2 and DRD3 ) Polymorphisms and Smoking Behaviour in a Malay Male Cohort.

Autor: Ruzilawati AB; Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia., Islam MA; Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia., Muhamed SKS; Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia., Ahmad I; Department of Family Medicine, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
Jazyk: angličtina
Zdroj: Biomolecules [Biomolecules] 2020 Dec 03; Vol. 10 (12). Date of Electronic Publication: 2020 Dec 03.
DOI: 10.3390/biom10121633
Abstrakt: Dopamine receptor and dopamine transporter genes polymorphisms have been associated with cigarette smoking behaviour in different populations. The aim of this case-control study was to evaluate polymorphisms in the dopamine transporter gene ( SLC6A3 (rs27072)) and the dopamine receptor genes ( DRD1 (rs686), DRD2 (rs1800497) and DRD3 (rs7653787)) and their contribution to smoking behaviour in a Malay male population. We identified 476 participants over the age of 18 years comprising 238 smokers and 238 non-smokers. Information such as age, height, weight, body mass index, systolic and diastolic blood pressures, marital status, and smoking status of close family members were taken. For the genetic study, we genotyped four genes ( SLC6A3 (rs27072), DRD1 (rs686), DRD2 (rs1800497) and DRD3 (rs7653787)) using the polymerase chain reaction-restriction fragment length polymorphism method and further confirmed our findings with sequencing. Dopamine receptor genes ( DRD1 , DRD2 and DRD3 ) were found to be associated with smoking behaviour in a Malay male population. The dopamine transporter gene ( SLC6A3 ) did not show this association. Significant differences were observed between smokers' and non-smokers' age, systolic blood pressure, marital status and family members who smoke. Smoking behaviour is significantly influenced by genetic variations of DRD1 , DRD2 and DRD3 in a Malay male population.
Databáze: MEDLINE
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