| Autor: |
Ribeiro-Filho J; Laboratório de Investigação em Genética e Hematologia Translacional, Instituto Gonçalo Moniz, FIOCRUZ, Salvador 40296-710, Brazil., da Silva Brandi J; Departamento de Farmácia, Centro de Ciências da Saúde, Unifaminas Centro Universitário, Muriaé 36880-000, Brazil., Ferreira Costa H; Faculdade de Medicina Nova Esperança, João Pessoa 58067-695, Brazil., Carla de Paula Medeiros K; Departamento de Morfologia, Centro de Biociências, UFRN, Natal 59072-970, Brazil., Alves Leite J; Departamento de Farmacologia, Instituto de Ciências Biológicas, UFG, Goiânia 74690-900, Brazil., Pergentino de Sousa D; Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, UFPB, João Pessoa 58051-900, Brazil., Regina Piuvezam M; Laboratório de Imunofarmacologia, Departamento de Fisiologia e Patologia, UFPB, João Pessoa 58051-900, Brazil. |
| Abstrakt: |
Carvone is a monoterpene found in nature in the form of enantiomers (S- and R-). While previous research has demonstrated the anti-inflammatory and anti-allergic effects of carvone, the influence of carvone enantiomeric composition on its anti-allergic activity remains to be investigated. This study aimed to evaluate the anti-allergic activity of carvone enantiomers in a murine model of airway allergic inflammation induced by sensitization and challenge with ovalbumin (OVA). The oral treatment with R-carvone or S-carvone 1 h before each challenge inhibited the number of leukocytes and eosinophils in the bronchoalveolar lavage (BAL). R-carvone inhibited leukocyte infiltration and mucus production in the lung, which was correlated with decreased production of OVA-specific IgE in the serum and increased concentrations of IL-10 in the BAL. On the other hand, the administration of S-carvone had little inhibitory effect on inflammatory infiltration and mucus production in the lung, which might be associated with increased production of IFN-γ in the BAL. When administered 1 h before each sensitization, both enantiomers inhibited eosinophil recruitment to the BAL but failed in decreasing the titers of IgE in the serum of allergic mice. Our data indicate that carvone enantiomers differentially modulated IgE-mediated airway inflammation in mice. In conclusion, unlike S-carvone, R-carvone has the potential to be used in anti-allergic drug development. |
