Optical sensors of heterotrimeric G protein signaling.
| Autor: | Bondar A; Center for Nanobiology and Structural Biology, Institute of Microbiology of the Czech Academy of Sciences, Nove Hrady, Czech Republic.; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.; Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech Republic., Lazar J; Center for Nanobiology and Structural Biology, Institute of Microbiology of the Czech Academy of Sciences, Nove Hrady, Czech Republic.; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic. |
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| Jazyk: | angličtina |
| Zdroj: | The FEBS journal [FEBS J] 2021 Apr; Vol. 288 (8), pp. 2570-2584. Date of Electronic Publication: 2020 Dec 26. |
| DOI: | 10.1111/febs.15655 |
| Abstrakt: | Heterotrimeric G proteins are central mediators of cellular signal transduction. They receive, process, and transduce signals from G protein-coupled receptors to downstream effectors. Since their discovery, a number of optical sensors of G protein localisation and function have been developed and applied in living systems. In this minireview, we provide an overview of existing G protein-based sensors and the experimental approaches they utilise, with emphasis on live-cell imaging techniques. We outline recent advances, as well as identify current challenges and likely future directions in the field of G protein sensor development. (© 2020 Federation of European Biochemical Societies.) |
| Databáze: | MEDLINE |
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