Maternal pre-pregnancy underweight as a risk factor for the offspring: Survey of Neonates in Pomerania.

Autor: Domanski G; Dept. of Neonatology and Pediatric Intensive Care, University Medicine Greifswald, Greifswald, Germany., Lange AE; Dept. of Neonatology and Pediatric Intensive Care, University Medicine Greifswald, Greifswald, Germany., Ittermann T; Institute for Community Medicine, Div. SHIP - Clinical Epidemiological Research, University Medicine Greifswald, Greifswald, Germany., Fallenberg J; Dept. of Neonatology and Pediatric Intensive Care, University Medicine Greifswald, Greifswald, Germany., Allenberg H; Dept. of Neonatology and Pediatric Intensive Care, University Medicine Greifswald, Greifswald, Germany., Zygmunt M; Department of Gynecology and Obstetrics, University Medicine Greifswald, Greifswald, Germany., Heckmann M; Dept. of Neonatology and Pediatric Intensive Care, University Medicine Greifswald, Greifswald, Germany.
Jazyk: angličtina
Zdroj: Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2021 May; Vol. 110 (5), pp. 1452-1460. Date of Electronic Publication: 2020 Dec 10.
DOI: 10.1111/apa.15701
Abstrakt: Aim: The aim was to investigate socio-economic risk factors for maternal underweight before pregnancy and then associations of underweight with neonatal outcomes.
Methods: Data of 3401 mother-child dyads from the population-based birth cohort Survey of Neonates in Pomerania (SNiP) were analysed.
Results: Bivariate analysis showed that underweighted mothers were younger, smoked more often, had a lower equivalent income and lower socio-economic status (employment status and/or educational level) compared to women with normal weight. The final prediction model revealed that only younger maternal age (OR = 0.93; 95%-CI = 0.90-0.97) and maternal smoking during pregnancy (OR = 2.52; 95%-CI = 1.74-3.66) were associated with underweight. Compared to women with normal pre-pregnancy BMI, underweight women had an increased chance of premature labour (OR = 1.73; 95% CI: 1.29-2.31) and a reduced placental weight. The offspring of underweight women had an increased risk of late preterm birth (OR = 1.82; 95% CI: 1.21-2.74) and birthweight < 2500 g (OR = 1.91; 95% CI: 1.23-2.95).
Conclusion: Smoking during pregnancy and a younger age were identified as risk factors for maternal pre-pregnancy underweight which then was associated with late preterm birth and low birthweight.
(© 2020 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.)
Databáze: MEDLINE
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