Proteins from SARS-CoV-2 reduce T cell proliferation: A mirror image of sepsis.

Autor:	Avendaño-Ortiz J; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain.; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain., Lozano-Rodríguez R; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain.; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain., Martín-Quirós A; Emergency Department and Emergent Pathology Research Group, IdiPAZ La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain., Maroun-Eid C; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain., Terrón V; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain.; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain., Valentín J; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain.; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain., Montalbán-Hernández K; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain.; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain., Ruiz de la Bastida F; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain.; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain., García-Garrido MA; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain.; Emergency Department and Emergent Pathology Research Group, IdiPAZ La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain., Cubillos-Zapata C; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain.; CIBER of Respiratory Diseases (CIBERES), Madrid, Spain., Del Balzo-Castillo Á; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain.; Emergency Department and Emergent Pathology Research Group, IdiPAZ La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain., Aguirre LA; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain.; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain., López-Collazo E; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain.; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain.; CIBER of Respiratory Diseases (CIBERES), Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2020 Dec; Vol. 6 (12), pp. e05635. Date of Electronic Publication: 2020 Nov 30.
DOI:	10.1016/j.heliyon.2020.e05635
Abstrakt:	Increased cytokine levels, acute phase reactants and immune checkpoint expression changes have been described in patients with Coronavirus Disease 2019 (COVID-19). Here, we have reported a monocyte polarization towards a low HLA-DR and high PD-L1 expression after long exposure to proteins from SARS-CoV-2. Moreover, CD86 expression was also reduced over SARS-CoV-2 proteins exposure. Additionally, T-cells proliferation was significantly reduced after stimulation with these proteins. Eventually, patients with long-term SARS-CoV-2 infection also exhibited a significant blockade of T-cells proliferation. Competing Interests: The authors declare no conflict of interest. (© 2020 Published by Elsevier Ltd.)
Databáze:	MEDLINE
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